Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.71 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.71 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.71 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.71 |
| ▸ | TSHR | P16473 | 2/20 | 0.71 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.71 |
| ▸ | CDC42 | P60953 | 1/20 | 0.71 |
| ▸ | RAC1 | P63000 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | APP | P05067 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.53 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.53 |
| ▸ | ALB | P02768 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | RARB | P10826 | 1/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL350067 | 1.00 | PTGS2 (0.71) | PTGS2AKR1C3PTGS1AKR1C2TSHR | |
| SCHEMBL2370631 | 1.00 | PTGS2 (0.71) | PTGS2AKR1C3PTGS1AKR1C2TSHR | |
| SCHEMBL28662721 | 0.98 | PTGS2 (0.69) | PTGS2AKR1C3PTGS1AKR1C2TSHR | |
| SCHEMBL1678493 | 0.94 | PTGS2 (0.67) | PTGS2AKR1C3PTGS1AKR1C2TSHR | |
| SCHEMBL4252394 | 0.91 | PTGS2 (0.61) | PTGS2AKR1C3PTGS1AKR1C2TSHR | |
| Anisole SCHEMBL28171713 | 0.88 | PTGS1 (0.62) | PTGS2AKR1C3PTGS1AKR1C2TSHR | |
| Fluorobenzene SCHEMBL27542547 | 0.88 | CYP2C19 (0.59) | PTGS2AKR1C3PTGS1AKR1C2TSHR | |
| SCHEMBL20608577 | 0.88 | PTGS2 (0.56) | PTGS2AKR1C3PTGS1AKR1C2TSHR | |
| Mequinol SCHEMBL28271410 | 0.86 | PTGS2 (0.55) | PTGS2AKR1C3PTGS1AKR1C2TSHR | |
| SCHEMBL8834311 | 0.85 | MEN1 (0.54) | PTGS2AKR1C3PTGS1AKR1C2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024015797-A1 | PEPTIDE DERIVATIVES AND RELATED USES AS OREXIN AGONISTS | CENTESSA PHARMACEUTICALS (OREXIA) LIMITED (GB) | 2024-01-18 | — | — | WO | disclosed |
| EP-2251316-B1 | METHOD FOR PRODUCING OPTICALLY ACTIVE ESTER AND METHOD FOR PRODUCING OPTICALLY ACTIVE CARBOXYLIC ACID | TOKYO UNIV OF SCIENCE EDUCATIONAL FOUNDATION ADMINISTRATIVE ORGANIZATION (JP) | 2018-02-21 | — | — | EP | disclosed |
| US-8115008-B2 | Method for producing optically active ester and method for producing optically active carboxylic acid | TOKYO UNIVERSITY OF SCIENCE EDUCATION FOUNDATION ADMINISTRATIVE ORGANIZATION (JP) | 2012-02-14 | — | — | US | disclosed |
| EP-2251316-A1 | METHOD FOR PRODUCING OPTICALLY ACTIVE ESTER AND METHOD FOR PRODUCING OPTICALLY ACTIVE CARBOXYLIC ACID | Tokyo University Of Science Educational Foundation Administrative Organization (JP) | 2010-11-17 | — | — | EP | disclosed |
| US-20100234610-A1 | METHOD FOR PRODUCING OPTICALLY ACTIVE ESTER AND METHOD FOR PRODUCING OPTICALLY ACTIVE CARBOXYLIC ACID | TOKYO UNIVERSITY OF SCIENCE EDUCATIONAL FOUNDATION ADMINISTRATIVE ORGANIZATION (JP) | 2010-09-16 | — | — | US | disclosed |
| WO-2007137874-A2 | IMIDAZOLIDINE DERIVATIVES, USES THEREFOR, PREPARATION THEREOF AND COMPOSITIONS COMPRISING SUCH | GALAPAGOS SAS (FR) | 2007-12-06 | — | — | WO | disclosed |
| US-5438118-A | Peptide mimics having constrained peptide backbone | SMITHKLINE BEECHMAN CORP. (US) | 1995-08-01 | — | — | US | disclosed |
| EP-0559793-A4 | — | — | 1994-04-27 | — | — | EP | disclosed |
| EP-0559793-A1 | HIV PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-09-15 | — | — | EP | disclosed |
| WO-1992009297-A1 | HIV PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234610-A1 | METHOD FOR PRODUCING OPTICALLY ACTIVE ESTER AND METHOD FOR PRODUCING OPTICALLY ACTIVE CARBOXYLIC ACID | ACADM, ADH5, ALDH7A1 | PTGS2 1254/4885AKR1C3 462/4885PTGS1 820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.