Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | CASP3 | P42574 | 1/20 | 0.67 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.67 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.67 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.67 |
| ▸ | THRA | P10827 | 2/20 | 0.59 |
| ▸ | THRB | P10828 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.53 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | CBS | P35520 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27463271 | 0.90 | DPP4 (0.81) | DPP4TDP1NPC1RAB9ACASP3 | |
| SCHEMBL3070677 | 0.86 | TDP1 (0.89) | DPP4TDP1NPC1RAB9ACASP3 | |
| SCHEMBL5991486 | 0.85 | DPP4 (0.73) | DPP4TDP1NPC1RAB9ACASP3 | |
| SCHEMBL8559822 | 0.84 | TDP1 (0.85) | DPP4TDP1NPC1RAB9ACASP3 | |
| SCHEMBL9242650 | 0.84 | TDP1 (0.85) | DPP4TDP1NPC1RAB9ACASP3 | |
| SCHEMBL7426101 | 0.84 | TDP1 (0.85) | DPP4TDP1NPC1RAB9ACASP3 | |
| SCHEMBL3208131 | 0.84 | DPP4 (0.71) | DPP4TDP1NPC1RAB9ACASP3 | |
| SCHEMBL8894978 | 0.84 | MAPT (0.74) | DPP4TDP1NPC1RAB9ACASP3 | |
| SCHEMBL7704524 | 0.82 | DPP4 (0.69) | DPP4TDP1NPC1RAB9ACASP3 | |
| SCHEMBL8896277 | 0.81 | TDP1 (0.79) | DPP4TDP1NPC1RAB9ACASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39072-E1 | 2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same | MITSUBISHI PHARMA CORPORATION (JP) | 2006-04-18 | — | — | US | disclosed |
| EP-1319651-B1 | 2-Aminopropane-1,3-diol compound, pharmaceutical use thereof and synthetic intermediates therefor | MITSUBISHI PHARMA CORP (JP) | 2005-06-29 | — | — | EP | disclosed |
| EP-1002792-B1 | 2-AMINOPROPANE-1,3-DIOL COMPOUNDS, MEDICINAL USE THEREOF, AND INTERMEDIATES IN SYNTHESIZING THE SAME | MITSUBISHI PHARMA CORP (JP) | 2004-07-14 | — | — | EP | disclosed |
| EP-1319651-A2 | 2-Aminopropane-1,3-diol compound, pharmaceutical use thereof and synthetic intermediates therefor | Mitsubishi Pharma Corporation (JP) | 2003-06-18 | — | — | EP | disclosed |
| US-6214873-B1 | PREVENTION OR SUPPRESION OF REJECTION OF ORGANS OR BONE MARROW TRANSPLANTATION; TREATMENT OF AUTOIMMUNE DISEASES OR ALLERGIC DISEASES; DECREASE IN TOXICITY AND HIGHER SAFETY | WELFIDE CORPORATION (JP) | 2001-04-10 | — | — | US | disclosed |
| EP-1002792-A1 | 2-AMINOPROPANE-1,3-DIOL COMPOUNDS, MEDICINAL USE THEREOF, AND INTERMEDIATES IN SYNTHESIZING THE SAME | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2000-05-24 | — | — | EP | disclosed |