Sugi Predict

Sugi Predict / Compounds / SCHEMBL5994233

SCHEMBL5994233

SCHEMBL5994233

Clc1[c]c(Cl)c2ccccc2c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.41
▸ HSD17B10 Q99714 4/20 0.41
▸ HIF1A Q16665 2/20 0.41
▸ CYP1B1 Q16678 1/20 0.41
▸ L3MBTL1 Q9Y468 2/20 0.40
▸ CYP2A6 P11509 6/20 0.39
▸ CYP1A2 P05177 5/20 0.39
▸ TRPM4 Q8TD43 1/20 0.37
▸ TSHR P16473 2/20 0.36
▸ TDP1 Q9NUW8 1/20 0.36
▸ HTR2A P28223 1/20 0.35
▸ NQO2 P16083 1/20 0.35
▸ HPGD P15428 2/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ GLA P06280 1/20 0.34
▸ CYP2C19 P33261 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ CYP3A4 P08684 1/20 0.33
▸ CA1 P00915 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29019737 0.78 TRPM4 (0.43) ALDH1A1HSD17B10HIF1ACYP1B1L3MBTL1
SCHEMBL29019716 0.78 TRPM4 (0.43) ALDH1A1HSD17B10HIF1ACYP1B1L3MBTL1
SCHEMBL1392086 0.75 — —
SCHEMBL27994733 0.75 TRPM4 (0.36) ALDH1A1HSD17B10HIF1ACYP1B1L3MBTL1
SCHEMBL29094151 0.74 NQO1 (0.38) ALDH1A1HSD17B10HIF1ACYP1B1L3MBTL1
SCHEMBL29061120 0.74 ALDH1A1 (0.34) ALDH1A1HSD17B10HIF1ACYP1B1L3MBTL1
SCHEMBL5599012 0.74 ALDH1A1 (0.41) ALDH1A1HSD17B10HIF1ACYP1B1L3MBTL1
SCHEMBL1392604 0.72 — —
SCHEMBL8125964 0.71 L3MBTL1 (0.36) ALDH1A1L3MBTL1HPGDKDM4EMEN1
SCHEMBL1392648 0.70 — —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7109250-B2 Multimer forms of acylphosphines and their derivatives CIBA SPECIALTY CHEMICALS CORP. (US) 2006-09-19 — — US disclosed
US-7026017-B2 Photoinitiators for acrylic esters; reacting an acyl halide with a metal benzoyl phosphine; cable coatings, screen printing stencils, resist materials, colour filters, electrical encapsulation CIBA SPECIALTY CHEMICALS CORPORATION (US) 2006-04-11 — — US disclosed
US-6969733-B2 Photoinitiators CIBA SPECIALTY CHEMICALS CORPORATION (US) 2005-11-29 — — US disclosed
US-20050004247-A1 Multimer forms of acylphosphines and their derivatives CIBA SPECIALTY CHEMICALS CORP. 2005-01-06 — — US disclosed
US-6737549-B2 PHOTOINITIATORS FOR ACRYLATE COATINGS CIBA SPECIALTY CHEMICALS CORPORATION 2004-05-18 — — US disclosed
US-20030139485-A1 Photoinitiators WOLF JEAN-PIERRE (CH) 2003-07-24 — — US disclosed
US-20030130370-A1 Photoinitiators for acrylic esters; reacting an acyl halide with a metal benzoyl phosphine; cable coatings, screen printing stencils, resist materials, colour filters, electrical encapsulation WOLF JEAN-PIERRE (CH) 2003-07-10 — — US disclosed
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20020026049-A1 Photoinitiators for acrylate coatings CIBA SPECIALTY CHEMICALS CORP. 2002-02-28 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed
EP-0446175-A2 Mixture of photoinitiators CIBA-GEIGY AG (CH) 1991-09-11 — — EP disclosed
US-4719297-A Acylphosphine compounds and their use as photoinitiators BASF AKTIENGESELLSCHAFT (DE) 1988-01-12 — — US disclosed
US-4710523-A DISCOLORATION, WEAR RESISTANT SURFACE COATING, FINISHES, AND PRINTING INK BASF AKTIENGESELLSCHAFT (DE) 1987-12-01 — — US disclosed
US-4522693-A Photopolymerizable composition with acylphosphine sulfide photoinitiator and method BASF AKTIENGESELLSCHAFT (DE) 1985-06-11 — — US disclosed
US-4298738-A PHOTOINITIATORS IN PHOTOPOLYMERIZABLE COATINGS AND IMKS BASF AKTIENGESELLSCHAFT (DE) 1981-11-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030139485-A1 Photoinitiators DHCR24, NR1I3, CBR1 ALDH1A1 974/4885HSD17B10 611/4885HIF1A 2852/4885
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 ALDH1A1 3416/4885HSD17B10 56/4885HIF1A 4416/4885
US-20030130370-A1 Photoinitiators for acrylic esters; reacting an acyl halide with a metal benzoyl phosphine; cable coatings, screen printing stencils, resist materials, colour filters, electrical encapsulation SMARCC1, ARPC5L, DHCR24 ALDH1A1 1088/4885HSD17B10 435/4885HIF1A 3952/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 ALDH1A1 3984/4885HSD17B10 42/4885HIF1A 4573/4885
US-20020026049-A1 Photoinitiators for acrylate coatings DHCR24, NR5A1, NR2C2 ALDH1A1 835/4885HSD17B10 1097/4885HIF1A 4014/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.