Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.70 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.70 |
| ▸ | GSK3B | P49841 | 16/20 | 0.58 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.52 |
| ▸ | HTR3B | O95264 | 1/20 | 0.52 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.52 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1964521 | 1.00 | HTR3A (0.70) | HTR3ACHRNA7GSK3BHTR3EHTR3B | |
| SCHEMBL1964257 | 1.00 | HTR3A (0.70) | HTR3ACHRNA7GSK3BHTR3EHTR3B | |
| SCHEMBL1963670 | 0.92 | CHRNA7 (0.70) | HTR3ACHRNA7GSK3BHTR3EHTR3B | |
| SCHEMBL1963239 | 0.92 | CHRNA7 (0.70) | HTR3ACHRNA7GSK3BHTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL1963923 | 0.91 | CHRNA7 (0.69) | HTR3ACHRNA7GSK3BHTR3EHTR3B | |
| SCHEMBL5995368 | 0.88 | CHRNA7 (0.67) | HTR3ACHRNA7GSK3BHTR3EHTR3B | |
| SCHEMBL1963576 | 0.88 | CHRNA7 (0.67) | HTR3ACHRNA7GSK3BHTR3EHTR3B | |
| SCHEMBL1963569 | 0.88 | CHRNA7 (0.67) | HTR3ACHRNA7GSK3BHTR3EHTR3B | |
| SCHEMBL1965364 | 0.88 | CHRNA7 (0.67) | HTR3ACHRNA7GSK3BHTR3EHTR3B | |
| SCHEMBL2787737 | 0.88 | CHRNA7 (0.64) | HTR3ACHRNA7GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735306-A2 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, AND PREPARATION AND USES THEREOF | Memory Pharmaceuticals Corporation (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005092890-A2 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |