Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 18/20 | 0.76 |
| ▸ | SLC6A4 known ✓ | P31645 | 18/20 | 0.76 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.76 |
| ▸ | NOS2 | P35228 | 2/20 | 0.59 |
| ▸ | NOS3 | P29474 | 1/20 | 0.59 |
| ▸ | NOS1 | P29475 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5994772 | 1.00 | SLC6A2 (0.76) | SLC6A2SLC6A4SLC6A3NOS2NOS3 | |
| Fumaric Acid SCHEMBL5994525 | 0.94 | SLC6A2 (0.73) | SLC6A2SLC6A4SLC6A3NOS2NOS3 | |
| Fumaric Acid SCHEMBL5994529 | 0.94 | SLC6A2 (0.73) | SLC6A2SLC6A4SLC6A3NOS2NOS3 | |
| SCHEMBL5997358 | 0.90 | SLC6A2 (0.71) | SLC6A2SLC6A4SLC6A3NOS2NOS3 | |
| Fumaric Acid SCHEMBL5997410 | 0.90 | SLC6A2 (0.77) | SLC6A2SLC6A4SLC6A3 | |
| Fumaric Acid SCHEMBL5997414 | 0.90 | SLC6A2 (0.77) | SLC6A2SLC6A4SLC6A3 | |
| Fumaric Acid SCHEMBL5995707 | 0.89 | SLC6A2 (0.72) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| Fumaric Acid SCHEMBL5995705 | 0.89 | SLC6A2 (0.72) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| Fumaric Acid SCHEMBL5994537 | 0.87 | SLC6A2 (0.75) | SLC6A2SLC6A4SLC6A3 | |
| Fumaric Acid SCHEMBL5994533 | 0.87 | SLC6A2 (0.75) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060079554-A1 | Inhibitors of monomine uptake | ELI LILLY AND COMPANY | 2006-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079554-A1 | Inhibitors of monomine uptake | SLC6A2, SLC18A2, SLC6A3 | SLC6A2 1/4885SLC6A4 4/4885KCNH2 1448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.