Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 19/20 | 0.70 |
| ▸ | CHRNA3 | P32297 | 19/20 | 0.70 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.58 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4011571 | 0.87 | CHRNB2 (0.55) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL2955968 | 0.84 | CHRNB4 (0.53) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL2961067 | 0.83 | CHRNB4 (0.51) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL5987239 | 0.79 | CHRNB2 (0.74) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL2954949 | 0.79 | CHRNB2 (0.74) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL2961069 | 0.79 | CHRNB2 (0.74) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL2963531 | 0.78 | CHRNB4 (0.48) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL2958574 | 0.78 | CHRNB2 (0.72) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL5995974 | 0.76 | CHRNB4 (1.00) | CHRNB4CHRNA3 | |
| SCHEMBL5994016 | 0.74 | CHRNB4 (0.66) | CHRNB4CHRNA3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7067261-B2 | Methods and compositions for treatment of central nervous system disorders | TARGACEPT, INC. (US) | 2006-06-27 | — | — | US | disclosed |