Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 11/20 | 0.55 |
| ▸ | PPARD | Q03181 | 11/20 | 0.55 |
| ▸ | PPARA | Q07869 | 9/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5989831 | 0.89 | PPARG (0.63) | PPARGPPARDPPARATP53 | |
| SCHEMBL5992887 | 0.89 | PPARG (0.63) | PPARGPPARDPPARATP53 | |
| SCHEMBL5989827 | 0.89 | PPARG (0.63) | PPARGPPARDPPARATP53 | |
| SCHEMBL5990505 | 0.86 | PPARG (0.49) | PPARGPPARDPPARATP53ABCB1 | |
| SCHEMBL5989901 | 0.81 | PPARG (0.64) | PPARGPPARDPPARADHODH | |
| SCHEMBL5989905 | 0.81 | PPARG (0.64) | PPARGPPARDPPARADHODH | |
| SCHEMBL5992133 | 0.81 | PPARG (0.60) | PPARGPPARDPPARATP53ABCB1 | |
| SCHEMBL6054804 | 0.80 | PPARG (0.60) | PPARGPPARDPPARATP53ABCB1 | |
| SCHEMBL6054774 | 0.79 | PPARG (0.59) | PPARGPPARDPPARATP53 | |
| SCHEMBL5989778 | 0.78 | PPARG (0.60) | PPARGPPARDPPARATP53ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060257987-A1 | Ppar modulators | ELI LILLY AND COMPANY | 2006-11-16 | — | — | US | disclosed |
| EP-1660428-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019151-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-03-03 | — | — | WO | disclosed |