SCHEMBL5997174

SCHEMBL5997174

COc1ccccc1C1CC=NNC1=O

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.44
KMT2A Q03164 4/20 0.44
USP2 O75604 1/20 0.44
CYP19A1 P11511 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.43
PKM P14618 1/20 0.43
HTR2C P28335 2/20 0.42
ALDH1A1 P00352 7/20 0.41
TDP1 Q9NUW8 3/20 0.41
LMNA P02545 1/20 0.41
HPGD P15428 1/20 0.41
TSHR P16473 1/20 0.41
MAPT P10636 3/20 0.40
RECQL P46063 1/20 0.40
POLB P06746 1/20 0.39
HSD11B1 P28845 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7301409 0.77 GSK3B (0.31) MAPTPOLB
SCHEMBL9378595 0.72 HTR2C (0.46) MEN1KMT2AUSP2L3MBTL1HTR2C
SCHEMBL5309401 0.71 DDB1 (0.54) MEN1KMT2ACYP19A1HTR2CALDH1A1
SCHEMBL25575861 0.69 DDB1 (0.66) L3MBTL1PKMHTR2CALDH1A1TDP1
SCHEMBL15874851 0.68 CYP19A1 (0.47) MEN1KMT2AUSP2CYP19A1L3MBTL1
SCHEMBL1616886 0.68 CYP19A1 (0.47) MEN1KMT2AUSP2CYP19A1L3MBTL1
SCHEMBL30496207 0.68 CYP19A1 (0.47) MEN1KMT2AUSP2CYP19A1L3MBTL1
SCHEMBL10751241 0.68
SCHEMBL10690101 0.67 ALDH1A1 (0.48) MEN1KMT2AUSP2CYP19A1L3MBTL1
SCHEMBL30550385 0.66 POLB (0.63) MEN1KMT2AUSP2L3MBTL1PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7122198-B1 Fast dissolving composition with prolonged sweet taste PANACEA BIOTEC LIMITED (IN) 2006-10-17 US disclosed
US-5719197-A DRUG DELIVERY NOVEN PHARMACEUTICALS, INC. (US) 1998-02-17 US disclosed
US-5446070-A Flexible, finite, bioadhesive, therapeutical agent in solid form NOVER PHARMACEUTICALS, INC. (US) 1995-08-29 US disclosed
US-5204463-A Substituted methoxyphenyl-4,5 dihydro-3(2H)-pridazinones having cardiotonic and beta blocking activities GLAXO INC. (US) 1993-04-20 US disclosed