Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 13/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.60 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.60 |
| ▸ | KIT | P10721 | 5/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL4409536 | 0.91 | PDE10A (0.64) | PDE10APDE3APDE3BKIT | |
| SCHEMBL5994058 | 0.85 | PDE10A (0.72) | PDE10APDE3APDE3BKIT | |
| SCHEMBL4401287 | 0.79 | PDE10A (0.65) | PDE10APDE3APDE3B | |
| SCHEMBL4397682 | 0.77 | PDE10A (0.69) | PDE10APDE3APDE3BKIT | |
| SCHEMBL5513778 | 0.77 | PDE10A (0.69) | PDE10APDE3APDE3BKIT | |
| SCHEMBL5509404 | 0.77 | PDE10A (0.64) | PDE10APDE3APDE3BKIT | |
| SCHEMBL2725365 | 0.76 | PDE10A (1.00) | PDE10APDE3APDE3B | |
| SCHEMBL2451079 | 0.76 | PDE10A (1.00) | PDE10APDE3APDE3B | |
| SCHEMBL30123166 | 0.76 | PDE10A (1.00) | PDE10APDE3APDE3B | |
| SCHEMBL4404999 | 0.76 | PDE10A (1.00) | PDE10APDE3APDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060183763-A1 | Novel pyrrolidyl derivatives of heteroaromatic compounds | PFIZER INC | 2006-08-17 | — | — | US | claimed |
| US-20060183763-A1 | Novel pyrrolidyl derivatives of heteroaromatic compounds | PFIZER INC | 2006-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183763-A1 | Novel pyrrolidyl derivatives of heteroaromatic compounds | PDE12, PDE4A, PDE7A | PDE10A 9/4885PDE3A 10/4885PDE3B 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.