SCHEMBL2451079

SCHEMBL2451079

COc1cc2ncnc(N3CC[C@@H](Oc4cnc5ccccc5n4)C3)c2cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 20/20 1.00
PDE3B Q13370 15/20 1.00
PDE3A Q14432 15/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30123166 1.00 PDE10A (1.00) PDE10APDE3BPDE3A
SCHEMBL4404999 1.00 PDE10A (1.00) PDE10APDE3BPDE3A
SCHEMBL2725365 1.00 PDE10A (1.00) PDE10APDE3BPDE3A
SCHEMBL2732504 0.95 PDE10A (0.90) PDE10APDE3BPDE3A
SCHEMBL4546146 0.95 PDE10A (0.90) PDE10APDE3BPDE3A
SCHEMBL10064028 0.95 PDE10A (0.90) PDE10APDE3BPDE3A
SCHEMBL4546144 0.95 PDE10A (0.90) PDE10APDE3BPDE3A
SCHEMBL4545624 0.93 PDE10A (0.87) PDE10APDE3BPDE3A
SCHEMBL10063509 0.93 PDE10A (0.87) PDE10APDE3BPDE3A
SCHEMBL4545622 0.93 PDE10A (0.86) PDE10APDE3BPDE3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 233 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120041510-A Intracellular delivery method of functionalized modified carbon nanomaterial and light synergistic enhanced exogenous biomacromolecule 南京林业大学 2025-05-27 CN claimed
US-12201711-B2 Wax dispersions having conditioning properties BASF SE (DE) 2025-01-21 US claimed
EP-3801448-B1 WAX DISPERSIONS WITH CONDITIONING PROPERTIES BASF SE (DE) 2024-07-10 EP claimed
CN-117777976-A Composition, blocking removal system and blocking removal method 中国石油化工股份有限公司 2024-03-29 CN claimed
EP-4103161-B1 COMPOSITIONS AND USES THEREOF BENEVOLENTAI CAMBRIDGE LTD (GB) 2023-12-20 EP claimed
US-20230240956-A1 WAX DISPERSIONS HAVING CONDITIONING PROPERTIES BASF SE (DE) 2023-08-03 US claimed
US-20230149385-A1 COMPOSITIONS AND USES THEREOF Benevolentai Cambridge Limited (GB) 2023-05-18 US claimed
EP-4103161-A1 COMPOSITIONS AND USES THEREOF BenevolentAI Cambridge Limited (GB) 2022-12-21 EP claimed
CN-115484938-A Composition and use thereof 博善人工智能剑桥有限公司 2022-12-16 CN claimed
US-20160143912-A1 TREATMENT AND DIAGNOSIS OF CANCER AND PRECANCEROUS CONDITIONS USING PDE10A INHIBITORS AND METHODS TO MEASURE PDE10A EXPRESSION UNIVERSITY OF SOUTH ALABAMA (US) 2016-05-26 US claimed
EP-4312960-B1 HAIR CONDITIONER DOW GLOBAL TECHNOLOGIES LLC (US) 2026-05-20 EP disclosed
CN-122040878-A Sealing ring for fluorine silica gel and PTFE/carbon fiber combined shaft and preparation method thereof 宁波市迪恩光伏科技有限公司 2026-05-15 CN disclosed
CN-122037795-A Polishing composition and polishing method 东莞领航电子新材料有限公司 2026-05-15 CN disclosed
US-20260130838-A1 HAIR CARE FORMULATION DOW SILICONES CORP (US) 2026-05-14 US disclosed
US-12622862-B2 Hair conditioner formulation DOW GLOBAL TECHNOLOGIES LLC (US) 2026-05-12 US disclosed
WO-2012052556-A1 NOVEL HALOALKOXYQUINAZOLINES, AND PREPARATION AND USE THEREOF UNIVERSITÄT LEIPZIG (DE) 2012-04-26 WO disclosed
WO-2011110545-A1 IMIDAZO [1, 2 -A] PYRAZINE DERIVATIVES AND THEIR USE FOR THE PREVENTION OR TREATMENT OF NEUROLOGICAL, PSYCHIATRIC AND METABOLIC DISORDERS AND DISEASES JANSSEN PHARMACEUTICA NV (BE) 2011-09-15 WO disclosed
US-20090162286-A1 Phosphodiesterase 10 Inhibition as Treatment for Obesity-Related and Metabolic Syndrome-Related Conditions PFIZER INC. 2009-06-25 US disclosed
US-20090162286-A1 Phosphodiesterase 10 Inhibition as Treatment for Obesity-Related and Metabolic Syndrome-Related Conditions PFIZER INC. 2009-06-25 US disclosed
WO-2005120514-A1 PHOSPHODIESTERASE 10 INHIBITION AS TREATMENT FOR OBESITY-RELATED AND METABOLIC SYNDROME-RELATED CONDITIONS PFIZER PRODUCTS INC. (US) 2005-12-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230240956-A1 WAX DISPERSIONS HAVING CONDITIONING PROPERTIES ELOVL1, ELOVL5, CUTA PDE10A 381/4885PDE3B 1040/4885PDE3A 1065/4885
US-12622862-B2 Hair conditioner formulation DEGS1, DSG1, SDC1 PDE10A 4702/4885PDE3B 4687/4885PDE3A 4629/4885
US-20230149385-A1 COMPOSITIONS AND USES THEREOF PDE2A, PDE3A, PDE3B PDE10A 5/4885PDE3B 3/4885PDE3A 2/4885
US-12201711-B2 Wax dispersions having conditioning properties ELOVL1, ELOVL5, CUTA PDE10A 381/4885PDE3B 1040/4885PDE3A 1065/4885
US-20260130838-A1 HAIR CARE FORMULATION MALT1, IRS1, SHC1 PDE10A 1966/4885PDE3B 4396/4885PDE3A 3305/4885
US-20090162286-A1 Phosphodiesterase 10 Inhibition as Treatment for Obesity-Related and Metabolic Syndrome-Related Conditions PDE5A, PDE12, PDE2A PDE10A 7/4885PDE3B 6/4885PDE3A 4/4885
US-20160143912-A1 TREATMENT AND DIAGNOSIS OF CANCER AND PRECANCEROUS CONDITIONS USING PDE10A INHIBITORS AND METHODS TO MEASURE PDE10A EXPRESSION PDE4A, PDE7B, PDE2A PDE10A 12/4885PDE3B 8/4885PDE3A 6/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.