Sugi Predict

Sugi Predict / Compounds / SCHEMBL5999537

SCHEMBL5999537

SCHEMBL5999537

CCSc1ccc(NC(=O)c2cccc(CSCCC(=O)O)c2)c(-c2cc(C(=O)NCc3cccc(C(F)(F)F)c3)ccn2)c1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SLC34A2 O95436 1/20 0.70
▸ LMNA P02545 2/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ DDR1 Q08345 1/20 0.39
▸ MLYCD O95822 1/20 0.39
▸ ROCK2 O75116 3/20 0.39
▸ ROCK1 Q13464 1/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ PLA2G1B P04054 1/20 0.39
▸ CYP1A2 P05177 1/20 0.39
▸ CYP3A4 P08684 1/20 0.39
▸ GAA P10253 1/20 0.39
▸ CYP2D6 P10635 1/20 0.39
▸ CYP2C19 P33261 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ TDP1 Q9NUW8 1/20 0.39
▸ ATG4B Q9Y4P1 1/20 0.39
▸ MRGPRX4 Q96LA9 1/20 0.38
▸ MAPK14 Q16539 1/20 0.38
▸ KDM1A O60341 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16804638 0.94 SLC34A2 (0.66) SLC34A2LMNARAB9AMLYCDROCK2
SCHEMBL39846 0.91 SLC34A2 (0.63) SLC34A2LMNARAB9ADDR1MLYCD
SCHEMBL46452 0.91 SLC34A2 (0.69) SLC34A2LMNARAB9ADDR1MLYCD
SCHEMBL46800 0.90 SLC34A2 (0.70) SLC34A2LMNARAB9ADDR1MLYCD
SCHEMBL46719 0.90 SLC34A2 (0.72) SLC34A2LMNARAB9AMLYCDROCK2
SCHEMBL46670 0.89 SLC34A2 (0.68) SLC34A2LMNARAB9AMLYCDROCK2
SCHEMBL46758 0.89 SLC34A2 (0.77) SLC34A2LMNARAB9AMLYCDROCK2
SCHEMBL46730 0.89 SLC34A2 (0.70) SLC34A2LMNARAB9AROCK2ROCK1
SCHEMBL40103 0.88 SLC34A2 (0.78) SLC34A2LMNARAB9AMLYCDROCK2
SCHEMBL46448 0.88 SLC34A2 (0.69) SLC34A2LMNARAB9AMLYCDROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2590656-B1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX INC (US) 2017-11-15 — — EP claimed
EP-2590656-B1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX INC (US) 2017-11-15 — — EP disclosed
EP-2591354-B1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX INC (US) 2016-09-07 — — EP disclosed
US-8916569-B2 Compounds and methods for inhibiting phosphate transport ARDELYX, INC. (US) 2014-12-23 — — US disclosed
US-8916569-B2 Compounds and methods for inhibiting phosphate transport ARDELYX, INC. (US) 2014-12-23 — — US disclosed
US-20140023611-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. 2014-01-23 — — US disclosed
US-20140023611-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. 2014-01-23 — — US disclosed
WO-2012054110-A2 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. (US) 2012-04-26 — — WO disclosed
WO-2012006475-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT ARDELYX, INC. (US) 2012-01-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140023611-A1 COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT SLC10A2, SLC34A2, SLC34A3 SLC34A2 2/4885LMNA 3817/4885RAB9A 1038/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.