⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetamide SCHEMBL28167929 | 0.73 | — | — | |
| SCHEMBL11805228 | 0.70 | — | — | |
| Acetamide SCHEMBL28805681 | 0.70 | — | — | |
| Acetamide SCHEMBL1618593 | 0.70 | — | — | |
| SCHEMBL5694545 | 0.70 | — | — | |
| Acetamide SCHEMBL8787813 | 0.70 | — | — | |
| Acetamide SCHEMBL5461243 | 0.70 | — | — | |
| SCHEMBL5368675 | 0.67 | — | — | |
| SCHEMBL31058189 | 0.67 | — | — | |
| Acetamide SCHEMBL4953249 | 0.64 | LMNA (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11555013-B2 | Potent and selective inhibitors of monoamine transporters; method of making; and use thereof | THE USA, AS REPRESENTED BY THE SECRETARY, DHHS (US) | 2023-01-17 | — | — | US | disclosed |
| EP-4096647-A1 | TREATING ACUTE LIVER DISEASE WITH TLR-MIK INHIBITORS | Yeda Research and Development Co. Ltd (IL) | 2022-12-07 | — | — | EP | disclosed |
| US-20220362329-A1 | TREATING ACUTE LIVER DISEASE WITH TLR-MIK INIHIBITORS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2022-11-17 | — | — | US | disclosed |
| EP-2964611-B1 | POTENT AND SELECTIVE INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF | US HEALTH (US) | 2022-10-19 | — | — | EP | disclosed |
| US-20210130288-A1 | POTENT AND SELECTIVE INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2021-05-06 | — | — | US | disclosed |
| US-10913711-B2 | Potent and selective inhibitors of monoamine transporters; method of making; and use thereof | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2021-02-09 | — | — | US | disclosed |
| CN-111012781-A | Application of demethylenetetrahydroberberine hydrochloride in preparation of medicine for preventing or treating liver injury | 中国药科大学 | 2020-04-17 | — | — | CN | disclosed |
| US-10590074-B2 | Potent and selective inhibitors of monoamine transporters; method of making; and use thereof | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2020-03-17 | — | — | US | disclosed |
| US-20190185424-A1 | POTENT AND SELECTIVE INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2019-06-20 | — | — | US | disclosed |
| US-20180093947-A1 | POTENT AND SELECTIVE INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF | US HEALTH (US) | 2018-04-05 | — | — | US | disclosed |
| US-20130253060-A1 | Intramural Research Program of the National Institutes of Health, National Institute of Environmental Health Sciences (NIEHS) | BOARD OF SUPERVISORS FOR THE UNIVERSITY OF LOUISIANA SYSTEM, ACTING ON BEHALF OF THE UNIVERSITY OF LOUISIANA AT MONROE | 2013-09-26 | — | — | US | disclosed |
| EP-2585109-A2 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING ORGAN INJURY AND/OR DYSFUNCTION | The General Hospital Corporation (US) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011163308-A2 | COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING ORGAN INJURY AND/OR DYSFUNCTION | THE GENERAL HOSPITAL CORPORATION (US) | 2011-12-29 | — | — | WO | disclosed |
| US-20060084096-A1 | Biomarkers and expression profiles for toxicology | BOESS FRANZISKA | 2006-04-20 | — | — | US | disclosed |
| US-20060078921-A1 | Biomarkers and expression profiles for toxicology | BOESS FRANZISKA | 2006-04-13 | — | — | US | disclosed |
| US-20040005547-A1 | Biomarkers and expression profiles for toxicology | HOFFMANN-LA ROCHE INC. | 2004-01-08 | — | — | US | disclosed |
| EP-1344834-A2 | Methods for the toxicity prediction of a compound | F. HOFFMANN-LA ROCHE AG (CH) | 2003-09-17 | — | — | EP | disclosed |
| EP-0056637-B1 | 4(3H)-QUINAZOLINONE DERIVATIVES, PROCESS FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID COMPOUNDS | Ishikawa, Masayuki (JP) | 1985-07-24 | — | — | EP | disclosed |
| US-4451467-A | HYPOTENSIVE AGENTS | Ishikawa, Masayuki (JP) | 1984-05-29 | — | — | US | disclosed |
| EP-0056637-A1 | 4(3H)-quinazolinone derivatives, process for production thereof and pharmaceutical compositions comprising said compounds | Ishikawa, Masayuki (JP) | 1982-07-28 | — | — | EP | disclosed |