Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL1596054 | 0.95 | TDP1 (0.56) | TDP1TSHRLMNA | |
| Propylene Glycol SCHEMBL6536510 | 0.91 | TDP1 (0.46) | TDP1TSHR | |
| Propylene Glycol SCHEMBL9229109 | 0.84 | TDP1 (0.43) | TDP1TSHR | |
| Ethylene Glycol SCHEMBL1594585 | 0.84 | TSHR (0.37) | TSHR | |
| SCHEMBL10793983 | 0.81 | TSHR (0.35) | TDP1TSHRLMNA | |
| Propylene Glycol SCHEMBL694327 | 0.81 | TDP1 (0.67) | TDP1TSHRTHRBLMNA | |
| SCHEMBL5024280 | 0.79 | TSHR (0.41) | TDP1TSHR | |
| E968 SCHEMBL23673754 | 0.79 | LMNA (0.38) | TDP1TSHRLMNA | |
| Glycerin SCHEMBL330202 | 0.79 | LMNA (0.50) | TDP1TSHRTHRBLMNA | |
| E968 SCHEMBL731451 | 0.79 | LMNA (0.38) | TDP1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060058482-A1 | Method for preparing metal cyanide catalysts using polymerizable complexing agents | DOW GLOBAL TECHNOLOGIES LLC | 2006-03-16 | — | — | US | claimed |
| US-20020061970-A1 | Resin composition for coating material | KANSAI PAINT CO., LTD. (JP) | 2002-05-23 | — | — | US | disclosed |
| US-4950415-A | MIXTURE OF AN ESTER AND SOLID SURFACTANT | NALCO CHEMICAL COMPANY (US) | 1990-08-21 | — | — | US | disclosed |