Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 3/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | QSOX1 | O00391 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.35 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18482990 | 0.86 | NPC1 (0.37) | HDAC1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL19596094 | 0.85 | DRD4 (0.38) | HDAC1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL40129 | 0.85 | ALDH1A1 (0.48) | HDAC1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL19596026 | 0.84 | HDAC1 (0.43) | HDAC1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL18482261 | 0.84 | DRD4 (0.37) | HDAC1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL46886 | 0.84 | TAOK1 (0.44) | MEN1KMT2AAURKAALDH1A1LMNA | |
| SCHEMBL40061 | 0.84 | TAOK1 (0.44) | MEN1KMT2AAURKAALDH1A1LMNA | |
| SCHEMBL19595742 | 0.83 | DRD4 (0.37) | HDAC1IRAK4MAPTSMYD2 | |
| SCHEMBL19596012 | 0.83 | HTR2A (0.36) | HDAC1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL18482740 | 0.81 | DRD4 (0.36) | HDAC1NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |