Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.43 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19596026 | 0.88 | HDAC1 (0.43) | ALDH1A1MEN1KMT2AHDAC1SERPINE1 | |
| SCHEMBL6000465 | 0.85 | HDAC1 (0.40) | ALDH1A1MEN1KMT2AHDAC1NPC1 | |
| SCHEMBL19595685 | 0.83 | SLC34A2 (0.46) | MEN1KMT2AHDAC1SERPINE1NPC1 | |
| SCHEMBL45046 | 0.82 | LMNA (0.51) | ALDH1A1MEN1KMT2AGAAKDM4C | |
| SCHEMBL45047 | 0.82 | LMNA (0.51) | ALDH1A1MEN1KMT2AGAAKDM4C | |
| SCHEMBL18482995 | 0.82 | SIRT2 (0.38) | MEN1KMT2AHDAC1SERPINE1NPC1 | |
| SCHEMBL19595388 | 0.81 | MAPT (0.53) | ALDH1A1KDM4EMEN1KMT2AHDAC1 | |
| SCHEMBL39860 | 0.81 | SLC34A2 (0.53) | KDM4EMEN1KMT2AGAAKDM4C | |
| SCHEMBL18482990 | 0.81 | NPC1 (0.37) | ALDH1A1MEN1KMT2AHDAC1NPC1 | |
| SCHEMBL19596051 | 0.81 | SLC34A2 (0.44) | MEN1KMT2AHDAC1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| EP-2590656-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |