Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 6/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.32 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.31 |
| ▸ | RELA | Q04206 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | STAT1 | P42224 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL600388 | 0.91 | DGAT1 (0.35) | DGAT1SMN1; SMN2MAPTTTKALDH1A1 | |
| SCHEMBL599621 | 0.87 | DGAT1 (0.39) | DGAT1SMN1; SMN2MAPTTTKALDH1A1 | |
| SCHEMBL600086 | 0.87 | DGAT1 (0.40) | DGAT1SMN1; SMN2MAPTTTKALDH1A1 | |
| SCHEMBL10328371 | 0.82 | DGAT1 (0.34) | DGAT1NPC1RAB9AMTORRPTOR | |
| SCHEMBL583745 | 0.80 | DGAT1 (0.40) | DGAT1SMN1; SMN2MAPTTTKALDH1A1 | |
| SCHEMBL600387 | 0.80 | DGAT1 (0.39) | DGAT1SMN1; SMN2MAPTALDH1A1ALDH1A2 | |
| SCHEMBL7881088 | 0.80 | ALDH1A1 (0.38) | DGAT1SMN1; SMN2MAPTTTKALDH1A1 | |
| SCHEMBL2679962 | 0.80 | DGAT1 (0.38) | DGAT1SMN1; SMN2MAPTTTKALDH1A1 | |
| SCHEMBL1023126 | 0.80 | DGAT1 (0.38) | DGAT1SMN1; SMN2ALDH1A1HPGDNPC1 | |
| SCHEMBL594353 | 0.79 | DGAT1 (0.37) | DGAT1SMN1; SMN2MAPTALDH1A1ALDH1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417138-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | Schering Corporation (US) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |