Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | BCL9 | O00512 | 1/20 | 0.54 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.49 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.49 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.49 |
| ▸ | CES1 | P23141 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL28222061 | 0.96 | GAA (0.57) | GAABCL9CTNNB1ALDH1A1KMT2A | |
| SCHEMBL9276769 | 0.96 | GAA (0.57) | GAABCL9CTNNB1ALDH1A1KMT2A | |
| SCHEMBL15168 | 0.96 | GAA (0.61) | GAABCL9CTNNB1ALDH1A1KMT2A | |
| Ammonia Solution, Strong SCHEMBL19516242 | 0.94 | GAA (0.59) | GAABCL9CTNNB1ALDH1A1KMT2A | |
| SCHEMBL25236596 | 0.91 | GAA (0.56) | GAABCL9CTNNB1ALDH1A1KMT2A | |
| P-Nitrophenol SCHEMBL1960699 | 0.89 | GAA (0.54) | GAABCL9CTNNB1ALDH1A1KMT2A | |
| Ethylene Glycol SCHEMBL23277093 | 0.89 | BCL9 (0.55) | GAABCL9CTNNB1ALDH1A1KMT2A | |
| Pyridine SCHEMBL7907616 | 0.87 | MAPT (0.58) | GAABCL9CTNNB1ALDH1A1KMT2A | |
| SCHEMBL9486189 | 0.85 | GAA (0.57) | GAABCL9CTNNB1ALDH1A1KMT2A | |
| Bicarbonate SCHEMBL7985678 | 0.85 | GAA (0.61) | GAABCL9CTNNB1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114431-B2 | Apparatus comprising integrin specific ligand for use in promoting tissue growth; tissue repair; tissue engineering; prosthetics | GEORGIA TECH RESEARCH CORPORATION (US) | 2012-02-14 | — | — | US | disclosed |