SCHEMBL6002410

SCHEMBL6002410

CCCCON([C]=O)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 2/20 0.41
TSHR P16473 5/20 0.39
TDP1 Q9NUW8 2/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
CYP1A2 P05177 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
ALDH1A1 P00352 5/20 0.36
CYP3A4 P08684 2/20 0.36
MAPK1 P28482 2/20 0.36
NPC1 O15118 1/20 0.36
JAK2 O60674 1/20 0.36
RAB9A P51151 1/20 0.36
PAX8 Q06710 1/20 0.36
HPGD P15428 1/20 0.35
LMNA P02545 1/20 0.34
MAPT P10636 1/20 0.34
HSD17B10 Q99714 1/20 0.34
GLA P06280 1/20 0.34
TP53 P04637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6003113 0.95 LTA4H (0.41) LTA4HTSHRALDH1A1CYP3A4MAPK1
SCHEMBL8351569 0.93 TSHR (0.41) LTA4HTSHRALDH1A1CYP3A4MAPK1
SCHEMBL6002122 0.93 TSHR (0.41) LTA4HTSHRALDH1A1CYP3A4MAPK1
SCHEMBL4634276 0.82 ALDH1A1 (0.38) TSHRTDP1L3MBTL1ALDH1A1NPC1
SCHEMBL5830750 0.76 LTA4H (0.47) LTA4HTSHRTDP1L3MBTL1CYP1A2
SCHEMBL10444028 0.74 LTA4H (0.46) LTA4HTSHRTDP1L3MBTL1CYP1A2
SCHEMBL10444027 0.73 LTA4H (0.44) LTA4HTSHRTDP1L3MBTL1CYP1A2
SCHEMBL2911078 0.73 LTA4H (0.44) LTA4HTSHRTDP1L3MBTL1CYP1A2
SCHEMBL6002413 0.72 LTA4H (0.41) LTA4HTSHRTDP1L3MBTL1CYP1A2
SCHEMBL6002982 0.72 TSHR (0.46) LTA4HTSHRTDP1L3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102532162-B 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles OTSUKA PHARMA CO LTD 2015-05-27 CN disclosed
EP-1678185-A1 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2006-07-12 EP disclosed
WO-2005042542-A1 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2005-05-12 WO disclosed
US-5864043-A CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST KARL THOMAE GMBH (DE) 1999-01-26 US disclosed
US-5541229-A ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS DR. KARL THOMAE GMBH (DE) 1996-07-30 US disclosed
EP-0392317-B1 Benzimidazoles, drugs containing these compounds and process for their preparation THOMAE GMBH DR K (DE) 1996-01-03 EP disclosed
EP-0392317-A2 Benzimidazoles, drugs containing these compounds and process for their preparation Dr. Karl Thomae GmbH (DE) 1990-10-17 EP disclosed