Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.42 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.42 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL95910 | 0.86 | L3MBTL1 (0.47) | L3MBTL1NPC1RAB9ATDP1MAPK1 | |
| SCHEMBL95911 | 0.84 | NOTUM (0.57) | L3MBTL1NPC1RAB9ATDP1MAPK1 | |
| SCHEMBL2090201 | 0.81 | L3MBTL1 (0.39) | L3MBTL1NPC1RAB9ATDP1MAPK1 | |
| SCHEMBL96972 | 0.81 | ALDH1A1 (0.44) | L3MBTL1NPC1RAB9ATDP1MAPK1 | |
| SCHEMBL96973 | 0.80 | TDP1 (0.44) | L3MBTL1NPC1RAB9ATDP1MAPK1 | |
| SCHEMBL2090203 | 0.79 | KMT2A (0.50) | L3MBTL1NPC1RAB9ATDP1MAPK1 | |
| SCHEMBL18610908 | 0.71 | NPC1 (0.58) | L3MBTL1NPC1RAB9ATDP1MAPK1 | |
| SCHEMBL18611858 | 0.71 | NPC1 (0.54) | L3MBTL1NPC1RAB9ATDP1MAPK1 | |
| SCHEMBL30371288 | 0.69 | CYP2D6 (0.37) | MAPTTP53 | |
| SCHEMBL22556187 | 0.69 | CYP2D6 (0.37) | MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |