Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6002712 | 0.93 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1HPGDHDAC3HDAC1 | |
| SCHEMBL6003255 | 0.93 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1HPGDHDAC3HDAC1 | |
| SCHEMBL1698453 | 0.93 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1HPGDHDAC3HDAC1 | |
| SCHEMBL6003417 | 0.91 | — | — | |
| SCHEMBL6002695 | 0.82 | SMN1; SMN2 (0.65) | SMN1; SMN2ALDH1A1HPGDHDAC3HDAC1 | |
| SCHEMBL10587847 | 0.81 | ALDH1A1 (0.83) | SMN1; SMN2ALDH1A1HPGDHDAC3HDAC1 | |
| SCHEMBL2096797 | 0.81 | — | — | |
| SCHEMBL11212248 | 0.81 | KMT2A (0.58) | SMN1; SMN2ALDH1A1HPGDHDAC3HDAC1 | |
| SCHEMBL3520525 | 0.81 | GNAI3 (0.60) | SMN1; SMN2ALDH1A1HPGDHDAC3HDAC1 | |
| SCHEMBL15906221 | 0.81 | EPHX1 (0.50) | SMN1; SMN2ALDH1A1HPGDEPHX1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |