Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | TACR2 | P21452 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1609713 | 0.84 | HSD17B10 (0.55) | HSD17B10KCNH2MAOBAHRLMNA | |
| SCHEMBL9784248 | 0.77 | ALDH1A1 (0.40) | MAOBCYP2A6MEN1MAPTKMT2A | |
| SCHEMBL9491843 | 0.77 | ALDH1A1 (0.40) | MAOBCYP2A6MEN1MAPTKMT2A | |
| SCHEMBL5682112 | 0.77 | HSD17B10 (0.48) | HSD17B10KCNH2MAOBAHRLMNA | |
| SCHEMBL257322 | 0.77 | KCNH2 (0.51) | HSD17B10KCNH2MAOBAHRPTGS1 | |
| SCHEMBL8170937 | 0.77 | KCNH2 (0.51) | HSD17B10KCNH2MAOBAHRPTGS1 | |
| SCHEMBL293565 | 0.73 | HSD17B10 (0.48) | HSD17B10KCNH2MAOBAHRLMNA | |
| SCHEMBL27645313 | 0.71 | KCNH2 (0.53) | KCNH2MAOBLMNACYP2A6 | |
| SCHEMBL8116628 | 0.70 | KCNH2 (0.45) | HSD17B10KCNH2 | |
| SCHEMBL2186171 | 0.69 | ALDH1A1 (0.42) | HSD17B10LMNACYP2A6MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |