Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 8/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | SCN1A | P35498 | 1/20 | 0.31 |
| ▸ | SCN4A | P35499 | 1/20 | 0.31 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.31 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.31 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.31 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.31 |
| ▸ | SCN11A | Q9UI33 | 1/20 | 0.31 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1255254 | 0.80 | HTR2A (0.41) | HTR2ATACR1OPRM1CACNA1FAR | |
| SCHEMBL4722907 | 0.76 | OPRM1 (0.38) | HTR2ATACR1OPRM1 | |
| SCHEMBL4720205 | 0.74 | OPRM1 (0.36) | HTR2AOPRM1 | |
| SCHEMBL1255270 | 0.73 | HTR2A (0.41) | HTR2ATACR1SLC6A4OPRM1CACNA1F | |
| SCHEMBL4723024 | 0.71 | USP2 (0.40) | HTR2AOPRM1 | |
| SCHEMBL10430315 | 0.71 | HTR2A (0.39) | HTR2ATACR1SLC6A4OPRM1 | |
| SCHEMBL4436585 | 0.70 | HTR2A (0.44) | HTR2AOPRM1CACNA1FARPDE4A | |
| SCHEMBL654291 | 0.70 | HTR2A (0.47) | HTR2AOPRM1CACNA1FARPDE4A | |
| SCHEMBL10682672 | 0.67 | HTR2A (0.44) | HTR2ASLC6A4OPRM1CACNA1FAR | |
| SCHEMBL1254663 | 0.67 | HTR2A (0.44) | HTR2AOPRM1CACNA1FARPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |