Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 7/20 | 0.34 |
| ▸ | MAOA | P21397 | 4/20 | 0.34 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN4A | P35499 | 1/20 | 0.33 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
| ▸ | SCN11A | Q9UI33 | 1/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL654291 | 0.77 | HTR2A (0.47) | HTR2AOPRM1CACNA1FARPDE4A | |
| SCHEMBL2201139 | 0.74 | HTR2A (0.44) | HTR2AOPRM1MAOACACNA1FAR | |
| SCHEMBL1254663 | 0.74 | HTR2A (0.44) | HTR2AOPRM1CACNA1FARPDE4A | |
| SCHEMBL10682672 | 0.74 | HTR2A (0.44) | HTR2AOPRM1CACNA1FARPDE4A | |
| SCHEMBL1255270 | 0.74 | HTR2A (0.41) | HTR2AOPRM1MAOBMAOACACNA1F | |
| SCHEMBL6002896 | 0.70 | HTR2A (0.38) | HTR2AOPRM1CACNA1FARPDE4A | |
| SCHEMBL1255254 | 0.70 | HTR2A (0.41) | HTR2AOPRM1CACNA1FARPDE4A | |
| SCHEMBL2204712 | 0.69 | HTR2A (0.40) | HTR2AOPRM1MAOBMAOAKCNH2 | |
| SCHEMBL9571716 | 0.68 | HTR2A (0.39) | HTR2AOPRM1CACNA1FARPDE4A | |
| SCHEMBL6361063 | 0.68 | HTR2A (0.39) | HTR2AOPRM1MAOBMAOAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809369-B2 | Tetrahydroquinoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2014-08-19 | — | — | US | claimed |
| EP-2668165-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-12-04 | — | — | EP | claimed |
| WO-2012101068-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-08-02 | — | — | WO | claimed |
| US-20120190677-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | US | claimed |
| US-7439238-B2 | Antiparasitic artemisinin derivatives (endoperoxides) | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (HK) | 2008-10-21 | — | — | US | claimed |
| US-20070191354-A1 | Antiparasitic artemisinin derivatives (endoperoxides) | BAYER AKTIENGESELLSCHAFT (DE) | 2007-08-16 | — | — | US | claimed |
| US-20070021409-A1 | Antiparasitic artemisinin derivatives (endoperoxides) | BAYER AKTIENGESELLSCHAFT (DE) | 2007-01-25 | — | — | US | claimed |
| EP-1095042-B9 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | BAYER HEALTHCARE AG (DE) | 2006-07-05 | — | — | EP | claimed |
| EP-1655302-A2 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | Bayer HealthCare AG (DE) | 2006-05-10 | — | — | EP | claimed |
| EP-1095042-B1 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | BAYER HEALTHCARE AG (DE) | 2005-12-28 | — | — | EP | claimed |
| EP-1095042-A1 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | Bayer Aktiengesellschaft (DE) | 2001-05-02 | — | — | EP | claimed |
| WO-2000004024-A1 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | BAYER AKTIENGESELLSCHAFT (DE) | 2000-01-27 | — | — | WO | claimed |
| US-10111884-B2 | Methods and compositions for treating viral infections | HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. (IL) | 2018-10-30 | — | — | US | disclosed |
| EP-2838903-B1 | METHODS AND COMPOSITIONS FOR TREATING VIRAL INFECTIONS | UNIV HONG KONG SCIENCE & TECH (CN) | 2017-09-06 | — | — | EP | disclosed |
| US-9616067-B2 | Methods and compositions for treating viral infections | HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. (IL) | 2017-04-11 | — | — | US | disclosed |
| US-20170071952-A1 | METHODS AND COMPOSITIONS FOR TREATING VIRAL INFECTIONS | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2017-03-16 | — | — | US | disclosed |
| EP-1095043-A1 | TRIOXANE DERIVATIVES | The Hong Kong University of Science & Technology (HK) | 2001-05-02 | — | — | EP | disclosed |
| EP-1095042-A1 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | Bayer Aktiengesellschaft (DE) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000004024-A1 | ANTIPARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES) | BAYER AKTIENGESELLSCHAFT (DE) | 2000-01-27 | — | — | WO | disclosed |
| WO-2000004026-A1 | TRIOXANE DERIVATIVES | THE HONG KONG UNIVERSITY OF SCIENCE & TECHNOLOGY (CN) | 2000-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170071952-A1 | METHODS AND COMPOSITIONS FOR TREATING VIRAL INFECTIONS | MAVS, EIF2AK2, HAVCR2 | HTR2A 4401/4885OPRM1 4627/4885MAOB 3398/4885 |
| US-10111884-B2 | Methods and compositions for treating viral infections | MAVS, EIF2AK2, HAVCR2 | HTR2A 4401/4885OPRM1 4627/4885MAOB 3398/4885 |
| US-20120190677-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | RAB1A, RABL3, RAB7A | HTR2A 1107/4885OPRM1 994/4885MAOB 3381/4885 |
| US-20070021409-A1 | Antiparasitic artemisinin derivatives (endoperoxides) | DHPS, CASP10, FECH | HTR2A 3418/4885OPRM1 4613/4885MAOB 2832/4885 |
| US-20070191354-A1 | Antiparasitic artemisinin derivatives (endoperoxides) | DHPS, CASP10, FECH | HTR2A 3418/4885OPRM1 4613/4885MAOB 2832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.