Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 4/20 | 0.35 |
| ▸ | CA2 | P00918 | 4/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13873189 | 0.84 | SIGMAR1 (0.57) | SIGMAR1CYP2A6PDE10ADYRK1APTPRC | |
| SCHEMBL3816500 | 0.83 | SIGMAR1 (0.56) | SIGMAR1CYP2A6PDE10ADYRK1APTPRC | |
| SCHEMBL3813009 | 0.83 | SIGMAR1 (0.60) | SIGMAR1CYP2A6PDE10ADYRK1APTPRC | |
| SCHEMBL2091182 | 0.81 | CYP2A6 (0.61) | SIGMAR1CYP2A6PDE10ADYRK1APTPRC | |
| SCHEMBL3810261 | 0.81 | SIGMAR1 (0.49) | SIGMAR1CYP2A6PDE10ACA12CA2 | |
| SCHEMBL52071 | 0.80 | SIGMAR1 (0.60) | SIGMAR1CYP2A6PDE10ACA12CA2 | |
| SCHEMBL10368304 | 0.80 | SIGMAR1 (0.51) | SIGMAR1CYP2A6PDE10APTPRCPTPN6 | |
| SCHEMBL3816494 | 0.80 | SIGMAR1 (0.51) | SIGMAR1CYP2A6PDE10ADYRK1APTPRC | |
| SCHEMBL52010 | 0.80 | SIGMAR1 (0.51) | SIGMAR1CYP2A6PDE10ADYRK1APTPRC | |
| SCHEMBL47966 | 0.80 | SIGMAR1 (0.60) | SIGMAR1CYP2A6PDE10ADYRK1APTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |