Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25658467 | 0.85 | NPC1 (0.66) | HPGDUSP2ALDH1A1MAPTCYP1A2 | |
| SCHEMBL2095756 | 0.84 | HPGD (0.73) | HPGDUSP2ALDH1A1MAPTCYP1A2 | |
| SCHEMBL7125633 | 0.83 | ALDH1A1 (0.62) | HPGDUSP2ALDH1A1MAPTCYP1A2 | |
| SCHEMBL11578349 | 0.82 | HPGD (0.65) | HPGDUSP2ALDH1A1MAPTCYP1A2 | |
| SCHEMBL11486413 | 0.82 | HTT (0.61) | HPGDUSP2ALDH1A1MAPTCYP1A2 | |
| SCHEMBL2095753 | 0.81 | HPGD (0.68) | HPGDUSP2ALDH1A1MAPTCYP1A2 | |
| SCHEMBL10631063 | 0.81 | HPGD (0.72) | HPGDUSP2ALDH1A1MAPTCYP1A2 | |
| SCHEMBL497131 | 0.80 | POLB (0.72) | HPGDUSP2ALDH1A1MAPTCYP1A2 | |
| SCHEMBL11481933 | 0.78 | POLB (0.57) | HPGDUSP2ALDH1A1MAPTCYP1A2 | |
| SCHEMBL6333143 | 0.78 | MAPT (0.63) | HPGDUSP2ALDH1A1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |