Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 4/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.48 |
| ▸ | KDR | P35968 | 8/20 | 0.46 |
| ▸ | AURKA | O14965 | 4/20 | 0.46 |
| ▸ | MET | P08581 | 4/20 | 0.46 |
| ▸ | TEK | Q02763 | 4/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.46 |
| ▸ | AXL | P30530 | 3/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 3/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004737 | 0.96 | SRC (0.48) | SRCTGFBR1KDRAURKAMET | |
| SCHEMBL6004924 | 0.91 | KDR (0.57) | SRCTGFBR1KDRAURKAMET | |
| SCHEMBL6004243 | 0.90 | SRC (0.41) | SRCTGFBR1KDRAURKAMET | |
| SCHEMBL3895779 | 0.87 | FGFR2 (0.53) | SRCTGFBR1KDRAXLPDGFRA | |
| SCHEMBL6005288 | 0.87 | KDR (0.52) | SRCTGFBR1KDRAURKAMET | |
| Benzylamine SCHEMBL6004866 | 0.86 | KDR (0.46) | SRCTGFBR1KDRAURKAMET | |
| SCHEMBL6005276 | 0.85 | SRC (0.44) | SRCTGFBR1KDRAXLPDGFRA | |
| SCHEMBL6002948 | 0.84 | FGFR2 (0.47) | SRCTGFBR1KDRAXLPDGFRA | |
| SCHEMBL6004812 | 0.84 | FGFR2 (0.44) | SRCTGFBR1KDRMETAXL | |
| SCHEMBL6004093 | 0.84 | MET (0.45) | SRCTGFBR1KDRMETAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |