Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 12/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | CBFB | Q13951 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6003004 | 0.91 | TGFBR1 (0.46) | TGFBR1NPC1KDM4ESRCPKM | |
| SCHEMBL6005291 | 0.90 | TGFBR1 (0.48) | TGFBR1NPC1KDM4ESRCRAB9A | |
| SCHEMBL6004307 | 0.90 | TGFBR1 (0.52) | TGFBR1NPC1KDM4EALDH1A1LMNA | |
| SCHEMBL6004264 | 0.89 | TGFBR1 (0.48) | TGFBR1NPC1KDM4ESRCALDH1A1 | |
| SCHEMBL6004725 | 0.89 | TGFBR1 (0.48) | TGFBR1NPC1KDM4ESRCALDH1A1 | |
| SCHEMBL6004226 | 0.89 | TGFBR1 (0.48) | TGFBR1NPC1KDM4ERAB9AALDH1A1 | |
| SCHEMBL6004657 | 0.89 | TGFBR1 (0.57) | TGFBR1NPC1KDM4ESRCMETAP2 | |
| SCHEMBL6004134 | 0.88 | KDM4E (0.52) | TGFBR1NPC1KDM4ESRCMETAP2 | |
| SCHEMBL6004185 | 0.88 | TGFBR1 (0.59) | TGFBR1NPC1KDM4ERAB9AALDH1A1 | |
| SCHEMBL6004154 | 0.88 | TGFBR1 (0.47) | TGFBR1NPC1KDM4ESRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |