Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 10/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004231 | 0.92 | TGFBR1 (0.59) | TGFBR1NPC1KDM4E | |
| SCHEMBL6002965 | 0.88 | TGFBR1 (0.49) | TGFBR1NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL6002895 | 0.87 | TGFBR1 (0.48) | TGFBR1NPC1KDM4E | |
| SCHEMBL6004274 | 0.87 | TGFBR1 (0.48) | TGFBR1NPC1KDM4EMEN1KMT2A | |
| SCHEMBL3898480 | 0.87 | TGFBR1 (0.56) | TGFBR1 | |
| SCHEMBL6005291 | 0.87 | TGFBR1 (0.48) | TGFBR1NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL6004307 | 0.87 | TGFBR1 (0.52) | TGFBR1NPC1KDM4EALDH1A1MAPT | |
| SCHEMBL6004756 | 0.86 | TGFBR1 (0.56) | TGFBR1NPC1RAB9ARUNX1ATM | |
| SCHEMBL6004725 | 0.86 | TGFBR1 (0.48) | TGFBR1NPC1KDM4EALDH1A1 | |
| SCHEMBL6004226 | 0.86 | TGFBR1 (0.48) | TGFBR1NPC1RAB9AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |