Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | SOD1 | P00441 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.47 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL515973 | 0.85 | POLB (0.59) | KDM4EALDH1A1SMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL15295402 | 0.83 | ALDH1A1 (0.65) | KDM4EALDH1A1SMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL131598 | 0.83 | TP53 (0.59) | KDM4EALDH1A1SMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL31061915 | 0.83 | TP53 (0.59) | KDM4EALDH1A1SMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL13849636 | 0.83 | POLB (0.62) | KDM4EALDH1A1SMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL7750604 | 0.82 | PPARA (0.60) | CYP4F2CYP4A11PPARGPPARA | |
| Ammonia Solution, Strong SCHEMBL27668328 | 0.82 | TP53 (0.57) | KDM4EALDH1A1SMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL933459 | 0.80 | PLA2G4B (0.48) | SMN1; SMN2MAPK1L3MBTL1TSHRTDP1 | |
| SCHEMBL716796 | 0.80 | TSHR (0.47) | ALDH1A1SMN1; SMN2MAPK1TSHRCYP4F2 | |
| SCHEMBL59488 | 0.80 | KDM4E (0.61) | KDM4EALDH1A1SMN1; SMN2MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482484-B2 | Carboxylic acids and derivatives for the treatment of and preventing diabetes and dyslipidaemia | MERCK PATENT GMBH (DE) | 2009-01-27 | — | — | US | disclosed |
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |