Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 9/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | CCKAR | P32238 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8537088 | 0.82 | NOS2 (0.38) | CCKBRMEN1ALDH1A1KMT2ANOS2 | |
| SCHEMBL4701849 | 0.82 | NOS2 (0.38) | CCKBRMEN1ALDH1A1KMT2ANOS2 | |
| SCHEMBL8537085 | 0.82 | NOS2 (0.38) | CCKBRMEN1ALDH1A1KMT2ANOS2 | |
| SCHEMBL8532923 | 0.80 | NOS2 (0.38) | CCKBRMEN1ALDH1A1KMT2ANOS2 | |
| SCHEMBL8532921 | 0.80 | NOS2 (0.38) | CCKBRMEN1ALDH1A1KMT2ANOS2 | |
| SCHEMBL9865875 | 0.76 | CCKBR (0.57) | CCKBRCCKAR | |
| SCHEMBL18315504 | 0.76 | NOTCH1 (0.48) | CCKBRMEN1ALDH1A1KMT2ACCKAR | |
| SCHEMBL8533213 | 0.76 | CCKBR (0.57) | CCKBRCCKAR | |
| SCHEMBL15629495 | 0.76 | NOTCH1 (0.48) | CCKBRMEN1ALDH1A1KMT2ACCKAR | |
| SCHEMBL8533212 | 0.76 | CCKBR (0.57) | CCKBRCCKAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105509-B2 | Benzodiazepine derivatives as APP modulators | MERCK SHARP & DOHME LIMITED (GB) | 2006-09-12 | — | — | US | disclosed |