Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30629503 | 0.78 | HCAR1 (0.33) | NR4A2KDM4EMAPTMAPK1CYP1A2 | |
| SCHEMBL29404834 | 0.74 | PARP1 (0.50) | NR4A2KDM4EMAPTMAPK1CYP1A2 | |
| SCHEMBL6465602 | 0.74 | PARP1 (0.50) | NR4A2KDM4EMAPTMAPK1CYP1A2 | |
| SCHEMBL7007591 | 0.74 | LRRK2 (0.35) | NR4A2KDM4EMAPTMAPK1CYP1A2 | |
| SCHEMBL11479173 | 0.72 | DPP4 (0.46) | KDM4ELRRK2ALDH1A1HSD17B10AURKB | |
| SCHEMBL28250223 | 0.70 | ADRA2A (0.44) | NR4A2KDM4EMAPTMAPK1CYP1A2 | |
| SCHEMBL15057461 | 0.70 | TLR8 (0.40) | NR4A2KDM4EMAPTMAPK1CYP1A2 | |
| SCHEMBL15056561 | 0.70 | CYP17A1 (0.38) | NR4A2KDM4EMAPTMAPK1CYP1A2 | |
| SCHEMBL10758608 | 0.70 | PARP1 (0.46) | MAPTLRRK2ALDH1A1AURKAAURKB | |
| SCHEMBL15578362 | 0.70 | LRRK2 (0.30) | NR4A2KDM4EMAPTMAPK1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |