Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 11/20 | 0.45 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6005332 | 0.93 | TGFBR1 (0.47) | RETRIPK1RIPK3TGFBR1PKMYT1 | |
| SCHEMBL6004149 | 0.92 | TGFBR1 (0.46) | RETRIPK1RIPK3TGFBR1PKMYT1 | |
| SCHEMBL6005329 | 0.92 | TGFBR1 (0.45) | RETRIPK1RIPK3TGFBR1PKMYT1 | |
| SCHEMBL6002897 | 0.92 | TGFBR1 (0.46) | RETRIPK1RIPK3TGFBR1PKMYT1 | |
| SCHEMBL6004261 | 0.92 | TGFBR1 (0.48) | RETRIPK1RIPK3TGFBR1PKMYT1 | |
| SCHEMBL6004676 | 0.91 | TGFBR1 (0.46) | RETRIPK1RIPK3TGFBR1PKMYT1 | |
| SCHEMBL6004802 | 0.91 | TGFBR1 (0.48) | RETRIPK1RIPK3TGFBR1PKMYT1 | |
| SCHEMBL6004764 | 0.86 | TGFBR1 (0.44) | RETRIPK1RIPK3TGFBR1PKMYT1 | |
| SCHEMBL6002905 | 0.86 | TGFBR1 (0.44) | RETRIPK1RIPK3TGFBR1NPC1 | |
| SCHEMBL6004725 | 0.85 | TGFBR1 (0.48) | RETRIPK1RIPK3TGFBR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |