Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 10/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004844 | 0.92 | TGFBR1 (0.44) | TGFBR1CYP2A6PIM1PIM2KDM4E | |
| SCHEMBL6005332 | 0.91 | TGFBR1 (0.47) | TGFBR1KDM4ENPC1RETRIPK1 | |
| SCHEMBL6004676 | 0.89 | TGFBR1 (0.46) | TGFBR1KDM4ENPC1RETRIPK1 | |
| SCHEMBL6004802 | 0.89 | TGFBR1 (0.48) | TGFBR1KDM4ENPC1RETRIPK1 | |
| SCHEMBL6002897 | 0.88 | TGFBR1 (0.46) | TGFBR1KDM4ENPC1RETRIPK1 | |
| SCHEMBL6004764 | 0.86 | TGFBR1 (0.44) | TGFBR1KDM4ENPC1RETRIPK1 | |
| SCHEMBL6004149 | 0.86 | TGFBR1 (0.46) | TGFBR1KDM4ENPC1RETRIPK1 | |
| SCHEMBL6004158 | 0.86 | RET (0.47) | TGFBR1KDM4ENPC1RETRIPK1 | |
| SCHEMBL6004790 | 0.85 | TGFBR1 (0.47) | TGFBR1KDR | |
| SCHEMBL6005052 | 0.84 | TGFBR1 (0.44) | TGFBR1KDM4ENPC1RETRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |