Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 13/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6002953 | 0.93 | TGFBR1 (0.41) | TGFBR1KDM4ENPC1PDE10A | |
| SCHEMBL6005291 | 0.86 | TGFBR1 (0.48) | TGFBR1KDM4ENPC1 | |
| SCHEMBL6005267 | 0.84 | TGFBR1 (0.46) | TGFBR1KDM4ENPC1 | |
| SCHEMBL6002943 | 0.84 | TGFBR1 (0.47) | TGFBR1KDM4ENPC1 | |
| SCHEMBL6004154 | 0.84 | TGFBR1 (0.47) | TGFBR1KDM4ENPC1 | |
| SCHEMBL6002945 | 0.83 | TGFBR1 (0.44) | TGFBR1KDM4ENPC1 | |
| SCHEMBL6003004 | 0.83 | TGFBR1 (0.46) | TGFBR1KDM4ENPC1 | |
| SCHEMBL6004186 | 0.83 | TGFBR1 (0.44) | TGFBR1KDM4ENPC1 | |
| SCHEMBL6002921 | 0.81 | TGFBR1 (0.44) | TGFBR1KDM4ENPC1 | |
| SCHEMBL6004307 | 0.81 | TGFBR1 (0.52) | TGFBR1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |