Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.44 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
| ▸ | FAP | Q12884 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 7/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 6/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4721256 | 0.87 | TLR7 (0.46) | TLR7MAPK14NR3C2PREPFAP | |
| SCHEMBL4721253 | 0.83 | TLR7 (0.47) | TLR7MAPK14NR3C2CSNK1DCSNK1E | |
| SCHEMBL4760720 | 0.82 | MAPK14 (0.51) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL6002781 | 0.80 | CSNK1E (0.47) | MAPK14PREPFAPCSNK1DCSNK1E | |
| SCHEMBL4720103 | 0.79 | RAB9A (0.49) | MAPK14NR3C2TGFBR1 | |
| SCHEMBL4825008 | 0.78 | MAPK14 (0.54) | TLR7MAPK14CSNK1DCSNK1E | |
| SCHEMBL4828575 | 0.78 | MAPK14 (0.48) | MAPK14CSNK1DCSNK1ETGFBR1 | |
| SCHEMBL4762808 | 0.77 | TGFBR1 (0.48) | TLR7MAPK14PREPFAPCSNK1D | |
| SCHEMBL6004529 | 0.77 | TLR7 (0.43) | TLR7PREPFAPCSNK1DCSNK1E | |
| SCHEMBL6004212 | 0.76 | ACKR3 (0.38) | TLR7MAPK14PREPFAPCSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060252807-A1 | Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders | KALYPSYS, INC. | 2006-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252807-A1 | Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders | MAPK1, MAP3K1, MAPK4 | TLR7 495/4885MAPK14 26/4885NR3C2 888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.