Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31366601 | 0.88 | GAA (0.58) | MAPTGAAMAPK14LMNAALDH1A1 | |
| SCHEMBL1569037 | 0.88 | GAA (0.58) | MAPTGAAMAPK14LMNAALDH1A1 | |
| SCHEMBL11320848 | 0.77 | NR4A1 (0.56) | MAPTMAPK14LMNAALDH1A1MEN1 | |
| SCHEMBL10931534 | 0.75 | MAPT (0.53) | MAPTGAAMAPK14LMNAALDH1A1 | |
| SCHEMBL342695 | 0.74 | TYK2 (0.49) | MAPTGAAMAPK14LMNAALDH1A1 | |
| SCHEMBL15628209 | 0.74 | ALOX15 (0.54) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL11320349 | 0.74 | AKR1C3 (0.53) | MAPTGAALMNAALDH1A1KMT2A | |
| SCHEMBL8956729 | 0.74 | KMT2A (0.44) | MAPTMAPK14LMNAALDH1A1MEN1 | |
| SCHEMBL35142 | 0.73 | HSD17B1 (0.49) | ALDH1A1POLB | |
| SCHEMBL49873 | 0.72 | KMT2A (0.65) | MAPTGAALMNAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641781-A2 | BENZODIAZEPINE CGRP RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005000807-A2 | BENZODIAZEPINE CGRP RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2005-01-06 | — | — | WO | disclosed |