Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 14/20 | 0.50 |
| ▸ | MET | P08581 | 3/20 | 0.44 |
| ▸ | SRC | P12931 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | TEK | Q02763 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004261 | 0.85 | TGFBR1 (0.48) | TGFBR1SRCKDM4ENPC1 | |
| SCHEMBL6002941 | 0.85 | NPSR1 (0.46) | TGFBR1METSRCAURKAKDR | |
| SCHEMBL6004330 | 0.84 | TGFBR1 (0.50) | TGFBR1METSRCAURKAKDR | |
| SCHEMBL6005494 | 0.84 | KDR (0.55) | TGFBR1METSRCAURKAKDR | |
| SCHEMBL6004802 | 0.83 | TGFBR1 (0.48) | TGFBR1METSRCAURKBKDM4E | |
| SCHEMBL6004307 | 0.83 | TGFBR1 (0.52) | TGFBR1NPSR1KDM4ENPC1 | |
| SCHEMBL6004842 | 0.83 | TGFBR1 (0.48) | TGFBR1KDM4ENPC1 | |
| SCHEMBL6002846 | 0.83 | TGFBR1 (0.48) | TGFBR1SRCKDM4ENPC1 | |
| SCHEMBL6004134 | 0.82 | KDM4E (0.52) | TGFBR1SRCKDM4ENPC1 | |
| SCHEMBL6004231 | 0.82 | TGFBR1 (0.59) | TGFBR1METAURKAKDRTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |