Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 10/20 | 0.59 |
| ▸ | MET | P08581 | 4/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | TEK | Q02763 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PRKACG | P22612 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004185 | 0.92 | TGFBR1 (0.59) | TGFBR1KDM4ENPC1 | |
| SCHEMBL6004931 | 0.87 | TGFBR1 (0.48) | TGFBR1METKDRCYP3A4PRKACG | |
| SCHEMBL6005388 | 0.87 | TGFBR1 (0.48) | TGFBR1METKDM4ENPC1 | |
| SCHEMBL6004802 | 0.87 | TGFBR1 (0.48) | TGFBR1METAURKBKDM4ENPC1 | |
| SCHEMBL3898480 | 0.87 | TGFBR1 (0.56) | TGFBR1PDGFRA | |
| SCHEMBL6004307 | 0.87 | TGFBR1 (0.52) | TGFBR1KDM4ENPC1 | |
| SCHEMBL6004942 | 0.86 | TGFBR1 (0.55) | TGFBR1KDM4ENPC1 | |
| SCHEMBL6004842 | 0.86 | TGFBR1 (0.48) | TGFBR1KDM4ENPC1 | |
| SCHEMBL6004261 | 0.86 | TGFBR1 (0.48) | TGFBR1KDM4ENPC1 | |
| SCHEMBL6002846 | 0.86 | TGFBR1 (0.48) | TGFBR1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |