Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 10/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6002905 | 0.92 | TGFBR1 (0.44) | TGFBR1RETKDRRIPK2MAPK14 | |
| SCHEMBL6002943 | 0.91 | TGFBR1 (0.47) | TGFBR1PIK3CAKDM4ENPC1 | |
| SCHEMBL6005267 | 0.89 | TGFBR1 (0.46) | TGFBR1PIK3CAMAPK1MAP4K4KDM4E | |
| SCHEMBL6005291 | 0.89 | TGFBR1 (0.48) | TGFBR1PIK3CARETMAPK1KDM4E | |
| SCHEMBL6003004 | 0.88 | TGFBR1 (0.46) | TGFBR1KDM4EHSD17B10HPGDNPC1 | |
| SCHEMBL6004154 | 0.87 | TGFBR1 (0.47) | TGFBR1KDM4ENPC1 | |
| SCHEMBL6004076 | 0.86 | TGFBR1 (0.46) | TGFBR1RETKDRRIPK2MAPK14 | |
| SCHEMBL6004938 | 0.86 | TGFBR1 (0.44) | TGFBR1MAP4K4KDM4ENPC1 | |
| SCHEMBL6004309 | 0.86 | TGFBR1 (0.44) | TGFBR1PIK3CAPIM1GRK5ACVR1 | |
| SCHEMBL6005329 | 0.86 | TGFBR1 (0.45) | TGFBR1RETKDRRIPK2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |