Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 10/20 | 0.88 |
| ▸ | CCKBR | P32239 | 7/20 | 0.88 |
| ▸ | CCKAR | P32238 | 4/20 | 0.88 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.63 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.59 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.59 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.59 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.59 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.59 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6005333 | 1.00 | SCN9A (0.88) | SCN9ACCKBRCCKARKCNH2PSEN1 | |
| SCHEMBL9526577 | 0.94 | SCN9A (1.00) | SCN9ACCKBRCCKARKCNH2 | |
| SCHEMBL9526573 | 0.94 | SCN9A (1.00) | SCN9ACCKBRCCKARKCNH2 | |
| SCHEMBL9526582 | 0.94 | SCN9A (1.00) | SCN9ACCKBRCCKARKCNH2 | |
| SCHEMBL6005356 | 0.91 | SCN9A (0.72) | SCN9ACCKBRCCKARPSEN1PSEN2 | |
| SCHEMBL9868387 | 0.86 | CCKBR (1.00) | SCN9ACCKBRCCKARKCNH2 | |
| SCHEMBL9866835 | 0.86 | CCKBR (1.00) | SCN9ACCKBRCCKARKCNH2 | |
| SCHEMBL7066281 | 0.85 | SCN9A (0.82) | SCN9ACCKBRCCKARKCNH2 | |
| SCHEMBL9385707 | 0.84 | SCN9A (0.81) | SCN9ACCKBRCCKARKCNH2 | |
| SCHEMBL6005656 | 0.84 | PSEN1 (0.80) | SCN9ACCKBRCCKARKCNH2PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105509-B2 | Benzodiazepine derivatives as APP modulators | MERCK SHARP & DOHME LIMITED (GB) | 2006-09-12 | — | — | US | disclosed |
| US-20040082572-A1 | Benzodiazepine derivatives as app modulators | MERCK SHARPE & DOHME LIMITED (GB) | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082572-A1 | Benzodiazepine derivatives as app modulators | BACE1, PSEN1, APP | SCN9A 305/4885CCKBR 642/4885CCKAR 838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.