Histidine

Histidine

SCHEMBL6005501

N[C@@H](Cc1cnc[nH]1)C(=O)O.[NaH]

nearest known ligand 0.97

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.97
SLC7A5 Q01650 1/20 0.97
CPB2 Q96IY4 1/20 0.57
ALDH1A1 P00352 4/20 0.56
HRH4 Q9H3N8 3/20 0.56
HRH3 Q9Y5N1 3/20 0.56
NFKB1 P19838 2/20 0.56
MEN1 O00255 1/20 0.56
GLA P06280 1/20 0.56
KMT2A Q03164 1/20 0.56
CYP1A2 P05177 1/20 0.56
THPO P40225 1/20 0.56
LMNA P02545 1/20 0.54
APEX1 P27695 1/20 0.54
BLM P54132 1/20 0.54
GABRA1 P14867 1/20 0.53
TSHR P16473 1/20 0.53
GABRR1 P24046 1/20 0.53
GABRR2 P28476 1/20 0.53
GABRA5 P31644 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL28435851 1.00 CYP3A4 (0.97) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL28211929 0.98 CYP3A4 (0.93) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL29050224 0.98 CYP3A4 (0.93) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL137600 0.98 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL30852263 0.98 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL3260 0.98 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL19974306 0.98 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
D-Histidine SCHEMBL288043 0.98 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL388560 0.98 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4
Histidine SCHEMBL28071764 0.98 CYP3A4 (1.00) CYP3A4SLC7A5CPB2ALDH1A1HRH4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240075457-A1 METHOD OF FORMING INTEGRATED COMPOSITE COMPRISING CONDUCTIVE CARBON NETWORK SUSTAERA INC (US) 2024-03-07 US claimed
CN-114874386-B Polymer-based ionic water-based lubricating additive and preparation method and application thereof 中国科学院兰州化学物理研究所 2023-04-04 CN claimed
CN-114874386-A Polymer-based ionic water-based lubricating additive and preparation method and application thereof 中国科学院兰州化学物理研究所 2022-08-09 CN claimed
CN-111185071-A Carbon dioxide absorbent and preparation method and application thereof 国家能源投资集团有限责任公司 2020-05-22 CN claimed
CN-109665917-A Suitable for the liquid suspension set meal fertilizer of solanaceous vegetables and its preparation and method of administration 福建省农业科学院土壤肥料研究所 2019-04-23 CN claimed
CN-104497455-B Polyvinyl alcohol-amino acid porous hydrogel composite material for cigarette 河南中烟工业有限责任公司 2017-01-25 CN claimed
CN-105924272-A Amino-acid-containing medium-element water-soluble discoloration fertilizer and dilution control method therefor 纪新强 2016-09-07 CN claimed
CN-105906428-A Liquid water-soluble color-changing fertilizer containing amino acid and medium element and dilution control method of fertilizer 纪新强 2016-08-31 CN claimed
CN-105906429-A Liquid water-soluble color-changing fertilizer containing amino acid and trace element and dilution control method of fertilizer 纪新强 2016-08-31 CN claimed
CN-103768071-B A kind of oral formulations treating diabetes 中国医药工业研究总院 2016-08-17 CN claimed
CN-105777389-A Water-soluble color-changing fertilizer containing amino acids and trace elements and dilution control method of fertilizer 纪新强 2016-07-20 CN claimed
CN-103458873-B For the aminoacid of the fatty-acylation of oral peptide delivery NOVO NORDISK A/S (DK) 2016-04-13 CN claimed
CN-104497455-A Polyvinyl alcohol-amino acid porous hydrogel composite material for cigarette CHINA TOBACCO HENAN IND CO LTD 2015-04-08 CN claimed
CN-103768071-A Oral preparation for treating diabetes CHINA STATE INST PHARM IND 2014-05-07 CN claimed
CN-103458873-A Fatty acid acylated amino acids for oral peptide delivery NOVO NORDISK AS 2013-12-18 CN claimed
CN-103191113-A Composition containing chloroquine phosphate TIANJIN JIAFAN BIOLOG TECHNOLOGY CO LTD 2013-07-10 CN claimed
CN-102697181-A Cigarette filter rod additive with harm reduction function and preparation and application method thereof CHINA TOBACCO HUNAN IND CO LTD 2012-10-03 CN claimed
CN-118791033-A Complexing agent for efficiently extracting calcium ions and preparation method and application thereof 济南大学 2024-10-18 CN disclosed
US-4889869-A ANTIALDOSTERONISM AGENTS CIBA-GEIGY CORPORATION (US) 1989-12-26 US disclosed
US-4758584-A Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups CIBA-GEIGY CORPORATION (US) 1988-07-19 US disclosed