Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 11/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.65 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.65 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.65 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.65 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.65 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.65 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.61 |
| ▸ | CCKAR | P32238 | 4/20 | 0.58 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.54 |
| ▸ | RBPJ | Q06330 | 1/20 | 0.54 |
| ▸ | GABRP | O00591 | 1/20 | 0.54 |
| ▸ | GABRD | O14764 | 1/20 | 0.54 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.54 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.54 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.54 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.54 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.54 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6005699 | 1.00 | CCKBR (0.68) | CCKBRKCNH2PSEN1PSEN2APH1B | |
| SCHEMBL6005656 | 0.89 | PSEN1 (0.80) | CCKBRKCNH2PSEN1PSEN2APH1B | |
| SCHEMBL6005767 | 0.87 | CCKBR (0.69) | CCKBRKCNH2PSEN1PSEN2APH1B | |
| SCHEMBL6005669 | 0.86 | PSEN1 (0.60) | CCKBRKCNH2PSEN1PSEN2APH1B | |
| SCHEMBL6005333 | 0.82 | SCN9A (0.88) | CCKBRKCNH2PSEN1PSEN2APH1B | |
| SCHEMBL6005336 | 0.82 | SCN9A (0.88) | CCKBRKCNH2PSEN1PSEN2APH1B | |
| SCHEMBL4699390 | 0.81 | HDAC3 (0.65) | CCKBRKCNH2PSEN1PSEN2APH1B | |
| SCHEMBL9525366 | 0.81 | CCKBR (1.00) | CCKBRKCNH2PSEN1PSEN2APH1B | |
| SCHEMBL9526276 | 0.81 | CCKBR (1.00) | CCKBRKCNH2PSEN1PSEN2APH1B | |
| SCHEMBL9526270 | 0.81 | CCKBR (1.00) | CCKBRKCNH2PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105509-B2 | Benzodiazepine derivatives as APP modulators | MERCK SHARP & DOHME LIMITED (GB) | 2006-09-12 | — | — | US | disclosed |
| US-20040082572-A1 | Benzodiazepine derivatives as app modulators | MERCK SHARPE & DOHME LIMITED (GB) | 2004-04-29 | — | — | US | disclosed |
| EP-1294702-A1 | BENZODIAZEPINE DERIVATIVES AS APP MODULATORS | MERCK SHARP & DOHME LTD. (GB) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001090084-A1 | BENZODIAZEPINE DERIVATIVES AS APP MODULATORS | MERCK SHARP & DOHME LIMITED (GB) | 2001-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082572-A1 | Benzodiazepine derivatives as app modulators | BACE1, PSEN1, APP | CCKBR 642/4885KCNH2 1795/4885PSEN1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.