Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PTPRC | P08575 | 1/20 | 0.45 |
| ▸ | PTPRG | P23470 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.41 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 2/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9109006 | 0.88 | CYP2C9 (0.49) | KMT2APPARGPPARAPNMTPTGS1 | |
| SCHEMBL6005718 | 0.86 | FPR2 (0.51) | KMT2APTPRGPPARGPPARAPNMT | |
| SCHEMBL6003758 | 0.86 | FPR2 (0.51) | KMT2APTPRGPPARGPPARAPNMT | |
| SCHEMBL6005310 | 0.86 | FPR2 (0.51) | KMT2APTPRGPPARGPPARAPNMT | |
| SCHEMBL6005803 | 0.85 | PPARA (0.50) | PPARGPPARAPNMTPTGS1PTGS2 | |
| SCHEMBL5434743 | 0.84 | PTGS1 (0.53) | KMT2APPARGPPARAPTGS1PTGS2 | |
| SCHEMBL6004995 | 0.82 | PNMT (0.41) | KMT2APPARGPPARAPNMTPTPN1 | |
| SCHEMBL17664412 | 0.79 | MEN1 (0.52) | KMT2AFPR2 | |
| SCHEMBL5434749 | 0.79 | KMT2A (0.44) | KMT2AFPR2 | |
| SCHEMBL6005468 | 0.77 | PPARG (0.43) | PTPRCPTPRGPPARGPPARAPNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105509-B2 | Benzodiazepine derivatives as APP modulators | MERCK SHARP & DOHME LIMITED (GB) | 2006-09-12 | — | — | US | disclosed |
| US-20040082572-A1 | Benzodiazepine derivatives as app modulators | MERCK SHARPE & DOHME LIMITED (GB) | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082572-A1 | Benzodiazepine derivatives as app modulators | BACE1, PSEN1, APP | KMT2A 3113/4885PTPRC 4388/4885PTPRG 3362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.