Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL439921 | 0.95 | CYP1A2 (0.42) | CYP1A2MGAMGAASIMGAM2 | |
| Ether SCHEMBL7559938 | 0.87 | CYP1A2 (0.48) | CYP1A2MGAMGAASIMGAM2 | |
| Propylene Glycol SCHEMBL7038031 | 0.86 | MAPT (0.43) | CYP1A2MGAMGAASIMGAM2 | |
| Butanol SCHEMBL28135887 | 0.85 | CYP1A2 (0.44) | CYP1A2MGAMGAASIMGAM2 | |
| Glycerin SCHEMBL442626 | 0.84 | LMNA (0.46) | CYP1A2MGAMGAASIMGAM2 | |
| E968 SCHEMBL3679613 | 0.84 | CYP1A2 (0.42) | CYP1A2MGAMGAASIMGAM2 | |
| Ethyl Propionate SCHEMBL104601 | 0.82 | MGAM (0.43) | CYP1A2MGAMGAASIMGAM2 | |
| Alcohol SCHEMBL811464 | 0.81 | GAA (0.50) | CYP1A2MGAMGAASIMGAM2 | |
| SCHEMBL92709 | 0.81 | GAA (0.55) | CYP1A2MGAMGAASIMGAM2 | |
| Propylene Glycol SCHEMBL3342302 | 0.80 | MAPT (0.47) | CYP1A2MGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603565-B1 | LATEX COATING COMPOSITIONS INCLUDING CARBOXY ESTER KETAL COALESCENTS, METHODS OF MANUFACTURE, AND USES THEREOF | SEGETIS INC (US) | 2015-10-07 | — | — | EP | disclosed |
| US-9074065-B2 | Latex coating compositions including carboxy ester ketal coalescents, methods of manufacture, and uses thereof | SEGETIS, INC. (US) | 2015-07-07 | — | — | US | disclosed |
| EP-2603565-A2 | LATEX COATING COMPOSITIONS INCLUDING CARBOXY ESTER KETAL COALESCENTS, METHODS OF MANUFACTURE, AND USES THEREOF | Segetis, Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012021826-A2 | LATEX COATING COMPOSITIONS INCLUDING CARBOXY ESTER KETAL COALESCENTS, METHODS OF MANUFACTURE, AND USES THEREOF | SEGETIS, INC. (US) | 2012-02-16 | — | — | WO | disclosed |
| US-20120041110-A1 | LATEX COATING COMPOSITIONS INCLUDING CARBOXY ESTER KETAL COALESCENTS, METHODS OF MANUFACTURE, AND USES THEROF | SEGETIS, INC. (US) | 2012-02-16 | — | — | US | disclosed |