Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.55 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 2/20 | 0.53 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.51 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GPR3 | P46089 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6007661 | 0.87 | PBRM1 (0.46) | IMPDH2IMPDH1PARP1PBRM1KDM4E | |
| SCHEMBL27872217 | 0.85 | IMPDH2 (0.58) | IMPDH2IMPDH1PARP1PBRM1CDK4 | |
| SCHEMBL30749415 | 0.84 | PARP1 (0.73) | IMPDH2IMPDH1PARP1PBRM1KDM4E | |
| SCHEMBL2183473 | 0.84 | PARP1 (0.73) | IMPDH2IMPDH1PARP1PBRM1KDM4E | |
| SCHEMBL30455376 | 0.84 | PARP1 (0.73) | IMPDH2IMPDH1PARP1PBRM1KDM4E | |
| SCHEMBL30006934 | 0.82 | IMPDH2 (0.55) | IMPDH2IMPDH1PARP1PBRM1KDM4E | |
| SCHEMBL6129592 | 0.82 | IMPDH2 (0.55) | IMPDH2IMPDH1PARP1PBRM1KDM4E | |
| SCHEMBL28318301 | 0.82 | IMPDH2 (0.55) | IMPDH2IMPDH1PARP1PBRM1CDK4 | |
| SCHEMBL2181558 | 0.81 | NR4A2 (0.55) | IMPDH2IMPDH1PARP1KDM4EABCG2 | |
| SCHEMBL31670359 | 0.81 | NR4A2 (0.55) | IMPDH2IMPDH1PARP1KDM4EABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309721-B2 | HSP90 inhibitory carbazole derivatives, compositions containing same and use thereof | SANOFI (FR) | 2012-11-13 | — | — | US | disclosed |
| US-20110166169-A1 | NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME AND USE THEREOF | SANOFI-AVENTIS (FR) | 2011-07-07 | — | — | US | disclosed |
| US-20060183022-A1 | Electrochemical cell | NEC TOKIN CORORATION (JP) | 2006-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166169-A1 | NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME AND USE THEREOF | HSP90AB2P, HSP90AB1, HSP90AA1 | IMPDH2 3926/4885IMPDH1 4250/4885PARP1 4296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.