Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL286231 | 0.88 | CYP2A6 (0.43) | KDM4EMAPTRXFP1MRGPRX4CA12 | |
| SCHEMBL5955864 | 0.86 | KDM4E (0.44) | KDM4EMAPTRXFP1MRGPRX4CA12 | |
| SCHEMBL22072190 | 0.85 | MRGPRX4 (0.43) | KDM4EMAPTRXFP1MRGPRX4CA12 | |
| SCHEMBL22374270 | 0.85 | KDM4E (0.41) | KDM4EMAPTRXFP1MRGPRX4CA12 | |
| SCHEMBL4076913 | 0.85 | ALDH1A1 (0.41) | KDM4EMAPTRXFP1MRGPRX4CA12 | |
| SCHEMBL3819761 | 0.85 | GAA (0.40) | KDM4EMAPTRXFP1MRGPRX4CA12 | |
| SCHEMBL27335284 | 0.82 | GSK3B (0.41) | KDM4EMAPTRXFP1MRGPRX4CA12 | |
| SCHEMBL29758971 | 0.82 | MRGPRX4 (0.39) | KDM4EMAPTRXFP1MRGPRX4CA12 | |
| SCHEMBL17022230 | 0.82 | MRGPRX4 (0.39) | KDM4EMAPTRXFP1MRGPRX4CA12 | |
| SCHEMBL23457135 | 0.82 | KDM4E (0.39) | KDM4EMAPTRXFP1MRGPRX4CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220213056-A1 | PROCESSES FOR PREPARING 2-(4-CHLOROPHENYL)-N-((2-(2,6-DIOXOPIPERIDIN-3-YL)-1-OXOISOINDOLIN-5-YL)METHYL)-2,2-DIFLUOROACETAMIDE | CELGENE CORP (US) | 2022-07-07 | — | — | US | disclosed |
| US-11312699-B2 | Processes for preparing 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide | CELGENE CORPORATION (US) | 2022-04-26 | — | — | US | disclosed |
| US-20210171493-A1 | PROCESSES FOR PREPARING 2-(4-CHLOROPHENYL)-N-((2-(2,6-DIOXOPIPERIDIN-3-YL)-1-OXOISOINDOLIN-5-YL)METHYL)-2,2-DIFLUOROACETAMIDE | CELGENE CORPORATION | 2021-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210171493-A1 | PROCESSES FOR PREPARING 2-(4-CHLOROPHENYL)-N-((2-(2,6-DIOXOPIPERIDIN-3-YL)-1-OXOISOINDOLIN-5-YL)METHYL)-2,2-DIFLUOROACETAMIDE | DCPS, DNMT1, DPYD | KDM4E 334/4885MAPT 2134/4885RXFP1 4832/4885 |
| US-20220213056-A1 | PROCESSES FOR PREPARING 2-(4-CHLOROPHENYL)-N-((2-(2,6-DIOXOPIPERIDIN-3-YL)-1-OXOISOINDOLIN-5-YL)METHYL)-2,2-DIFLUOROACETAMIDE | DCPS, DNMT1, DPYD | KDM4E 334/4885MAPT 2134/4885RXFP1 4832/4885 |
| US-11312699-B2 | Processes for preparing 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide | DCPS, DNMT1, DPYD | KDM4E 334/4885MAPT 2134/4885RXFP1 4832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.