Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PPIA | P62937 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.39 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.39 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29936995 | 1.00 | TDP1 (0.46) | TDP1ATMESPL1ALDH1A1HIF1A | |
| Hydrochloric Acid SCHEMBL28508306 | 0.98 | TDP1 (0.44) | TDP1ATMESPL1ALDH1A1HIF1A | |
| SCHEMBL29739473 | 0.92 | TDP1 (0.46) | TDP1ATMESPL1ALDH1A1HIF1A | |
| SCHEMBL600922 | 0.92 | TDP1 (0.46) | TDP1ATMESPL1ALDH1A1HIF1A | |
| SCHEMBL31693512 | 0.85 | TSHR (0.46) | TDP1ATMALDH1A1HIF1ACYP1A2 | |
| SCHEMBL214031 | 0.85 | TSHR (0.46) | TDP1ATMALDH1A1HIF1ACYP1A2 | |
| SCHEMBL772624 | 0.84 | CYP1A2 (0.48) | TDP1ALDH1A1CYP1A2TSHRMAPK1 | |
| SCHEMBL12593915 | 0.84 | TDP1 (0.52) | TDP1ATMESPL1ALDH1A1HIF1A | |
| SCHEMBL29580289 | 0.84 | TDP1 (0.52) | TDP1ATMESPL1ALDH1A1HIF1A | |
| SCHEMBL14578462 | 0.84 | TDP1 (0.52) | TDP1ATMESPL1ALDH1A1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 176 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118146138-B | Preparation method and application of 2-isopropoxy-5-methyl-4- (piperidin-4-yl) aniline hydrochloride | 广州安岩仁医药科技有限公司 | 2024-11-05 | — | — | CN | claimed |
| CN-118146138-A | Preparation method and application of 2-isopropoxy-5-methyl-4- (piperidin-4-yl) aniline hydrochloride | 广州安岩仁医药科技有限公司 | 2024-06-07 | — | — | CN | claimed |
| CN-114507142-A | Preparation process of 2-chloro-4-fluoro-5-nitrobenzaldehyde | 上海予君生物科技发展有限公司 | 2022-05-17 | — | — | CN | claimed |
| CN-119613399-A | Tetra-substituted benzoate compound containing alkoxy acetate substituent and application thereof | 江西天宇化工有限公司 | 2025-03-14 | — | — | CN | disclosed |
| US-20240409558-A1 | IRREVERSIBLE INHIBITORS OF KRAS | BIOMEA FUSION, INC. | 2024-12-12 | — | — | US | disclosed |
| CN-118993987-A | Preparation method of 5-methyl-2-isopropoxy-4- (4-piperidine) -aniline dihydrochloride monohydrate | 广州科锐特生物科技有限公司 | 2024-11-22 | — | — | CN | disclosed |
| CN-118146138-B | Preparation method and application of 2-isopropoxy-5-methyl-4- (piperidin-4-yl) aniline hydrochloride | 广州安岩仁医药科技有限公司 | 2024-11-05 | — | — | CN | disclosed |
| CN-118146138-B | Preparation method and application of 2-isopropoxy-5-methyl-4- (piperidin-4-yl) aniline hydrochloride | 广州安岩仁医药科技有限公司 | 2024-11-05 | — | — | CN | disclosed |
| US-20240317721-A1 | PYRAZOLYL DERIVATIVES AS INHIBITORS OF THE KRAS MUTANT PROTEIN | NOVARTIS AG (CH) | 2024-09-26 | — | — | US | disclosed |
| US-20240239788-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2024-07-18 | — | — | US | disclosed |
| US-20240239788-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2024-07-18 | — | — | US | disclosed |
| EP-0732942-A4 | ALKYL, AZIDO, ALKOXY, AND FLUORO-SUBSTITUTED AND FUSED QUINOXALINEDIONES AND THE USE THEREOF AS GLYCINE RECEPTOR ANTAGONISTS | COCENSYS INC (US) | 2000-03-22 | — | — | EP | disclosed |
| US-5977107-A | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones and the use thereof as glycine receptor antagonists | COCENSYS, INC. (US) | 1999-11-02 | — | — | US | disclosed |
| US-5631373-A | NERVOUS SYSTEM DISORDERS | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY AND THE UNIVERSITY OF OREGON, EUGENE OREGON (US) | 1997-05-20 | — | — | US | disclosed |
| EP-0732942-A1 | ALKYL, AZIDO, ALKOXY, AND FLUORO-SUBSTITUTED AND FUSED QUINOXALINEDIONES AND THE USE THEREOF AS GLYCINE RECEPTOR ANTAGONISTS | ACEA PHARMACEUTICALS, INC. (US) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995012417-A1 | ALKYL, AZIDO, ALKOXY, AND FLUORO-SUBSTITUTED AND FUSED QUINOXALINEDIONES AND THE USE THEREOF AS GLYCINE RECEPTOR ANTAGONISTS | ACEA PHARMACEUTICALS, INC. (US) | 1995-05-11 | — | — | WO | disclosed |
| US-4846875-A | PLANT GROWTH REGULATORS | FMC CORPORATION (US) | 1989-07-11 | — | — | US | disclosed |
| US-4846882-A | HALOBENZYL DERIVATIVES | FMC CORPORATION (US) | 1989-07-11 | — | — | US | disclosed |
| CN-87100152-A | The compound of weeding | — | 1987-08-12 | — | — | CN | disclosed |
| WO-1987004049-A1 | N-SUBSTITUTED TETRAHYDROPHTHALIMIDE HERBICIDAL COMPOUNDS AND INTERMEDIATES THEREFOR | FMC CORPORATION (US) | 1987-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240317721-A1 | PYRAZOLYL DERIVATIVES AS INHIBITORS OF THE KRAS MUTANT PROTEIN | KRAS, NRAS, APC | TDP1 3586/4885ATM 1119/4885ESPL1 1311/4885 |
| US-20240409558-A1 | IRREVERSIBLE INHIBITORS OF KRAS | KRAS, NRAS, TP53 | TDP1 2284/4885ATM 1435/4885ESPL1 1554/4885 |
| US-20240239788-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | KRAS, NRAS, HRAS | TDP1 2748/4885ATM 701/4885ESPL1 428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.