Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MME | P08473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17997419 | 0.85 | CYP1A2 (0.46) | KMT2AKDM4ECYP1A2CHRM5CHRM3 | |
| SCHEMBL25787315 | 0.84 | ALDH1A1 (0.37) | KMT2AKDM4ECYP1A2ALDH1A1MEN1 | |
| SCHEMBL18012255 | 0.80 | KDM4E (0.64) | KMT2AKDM4ECYP1A2 | |
| SCHEMBL16750982 | 0.80 | KDM4E (0.69) | KMT2AKDM4ECYP1A2 | |
| SCHEMBL24946116 | 0.78 | ALDH1A1 (0.50) | KMT2AKDM4EALDH1A1MEN1L3MBTL1 | |
| SCHEMBL25221272 | 0.77 | CYP1A2 (0.49) | KMT2AKDM4ECYP1A2CHRM5CHRM3 | |
| SCHEMBL5239178 | 0.77 | KDM4E (0.50) | KMT2AKDM4ECYP1A2CHRM5CHRM3 | |
| SCHEMBL15185854 | 0.77 | KDM4E (0.60) | KMT2AKDM4ECYP1A2CHRM5CHRM3 | |
| Hydrochloric Acid SCHEMBL25218542 | 0.76 | CYP1A2 (0.47) | KMT2AKDM4ECYP1A2CHRM5CHRM3 | |
| SCHEMBL18934853 | 0.76 | CYP1A2 (0.47) | KMT2AKDM4ECYP1A2CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713781-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005075439-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |