Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.63 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.53 |
| ▸ | BCL2 | P10415 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | GAA | P10253 | 7/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7713239 | 0.98 | ALDH1A1 (0.61) | ALDH1A1ALOX15HSD17B10MCL1BCL2 | |
| SCHEMBL335560 | 0.87 | ALDH1A1 (0.52) | ALDH1A1ALOX15HSD17B10MCL1BCL2 | |
| SCHEMBL31568748 | 0.87 | ALDH1A1 (0.52) | ALDH1A1ALOX15HSD17B10MCL1BCL2 | |
| SCHEMBL11630774 | 0.83 | TDP1 (0.56) | ALDH1A1ALOX15HSD17B10MCL1BCL2 | |
| SCHEMBL11190277 | 0.83 | NR1H2 (0.61) | ALDH1A1ALOX15HSD17B10MCL1BCL2 | |
| SCHEMBL10728850 | 0.82 | ALDH1A1 (0.53) | ALDH1A1ALOX15HSD17B10MCL1BCL2 | |
| SCHEMBL21301917 | 0.82 | ALDH1A1 (0.58) | ALDH1A1ALOX15HSD17B10MCL1BCL2 | |
| SCHEMBL11589722 | 0.82 | TP53 (0.58) | ALDH1A1ALOX15HSD17B10MCL1BCL2 | |
| SCHEMBL11196815 | 0.80 | ALDH1A1 (0.42) | ALDH1A1ALOX15HSD17B10MCL1BCL2 | |
| SCHEMBL11196256 | 0.80 | MCL1 (0.53) | ALDH1A1ALOX15HSD17B10MCL1BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0083204-A2 | 2-Aminophenol derivatives and process for their preparation | ONO PHARMACEUTICAL CO., LTD. (JP) | 1983-07-06 | — | — | EP | claimed |
| US-7132441-B2 | Immunosuppressive effects of administration of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor | G.D. SEARLE & CO. (US) | 2006-11-07 | — | — | US | disclosed |
| EP-0083204-A2 | 2-Aminophenol derivatives and process for their preparation | ONO PHARMACEUTICAL CO., LTD. (JP) | 1983-07-06 | — | — | EP | disclosed |