Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | FNTA | P49354 | 3/20 | 0.42 |
| ▸ | FNTB | P49356 | 3/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | WEE1 | P30291 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 5/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1538310 | 0.86 | MEN1 (0.59) | MEN1KMT2ARXFP1FNTAFNTB | |
| SCHEMBL5657749 | 0.83 | MEN1 (0.52) | MEN1KMT2ARXFP1FNTAFNTB | |
| SCHEMBL5657976 | 0.82 | MEN1 (0.51) | MEN1KMT2ARXFP1FNTAFNTB | |
| SCHEMBL5656275 | 0.80 | MEN1 (0.48) | MEN1KMT2ARXFP1FNTAFNTB | |
| SCHEMBL5027012 | 0.78 | LTB4R (0.37) | NUDT1CA12CA9 | |
| SCHEMBL7205333 | 0.78 | MEN1 (0.49) | MEN1KMT2ARXFP1FNTAFNTB | |
| SCHEMBL5550240 | 0.78 | MEN1 (0.49) | MEN1KMT2ARXFP1FNTAFNTB | |
| SCHEMBL6010190 | 0.78 | FNTA (0.47) | KMT2AFNTAFNTB | |
| SCHEMBL5722642 | 0.76 | MEN1 (0.52) | MEN1KMT2ARXFP1FNTAFNTB | |
| SCHEMBL5780432 | 0.76 | RXFP1 (0.52) | MEN1KMT2ARXFP1FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7067531-B2 | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-27 | — | — | US | disclosed |
| US-20030199547-A1 | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives | JANSSEN-CILAG S.A. (FR) | 2003-10-23 | — | — | US | disclosed |
| EP-1322644-A1 | FARNESYL TRANSFERASE INHIBITING 6-HETEROCYCLYLMETHYL QUINOLINONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024687-A1 | FARNESYL TRANSFERASE INHIBITING 6-HETEROCYCLYLMETHYL QUINOLINONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199547-A1 | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives | FNTA, FNTB, RCE1 | MEN1 1698/4885KMT2A 2978/4885RXFP1 2536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.